Therapeutic Targets Database
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TTD Drug ID: DNC010059

Drug Information
NameCOUMARIN
SynonymsCOUMARIN
IndicationNot AvailableExperimental    
Structure

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InChI1S/C15H16O5/c1-8(2)14(17)15(18)10-6-9-4-5-13(16)20-11(9)7-12(10)1
9-3/h4-7,14-15,17-18H,1H2,2-3H3
InChIKeyPMZIJDMODGMWOR-UHFFFAOYSA-N
Canonical SMILESCC(=C)C(C(C1=C(C=C2C(=C1)C=CC(=O)O2)OC)O)O    
TargetCarbonic anhydrase IInhibitor[1]
Carbonic anhydrase IIInhibitor[1]
Carbonic anhydrase IIIInhibitor[2]
Carbonic anhydrase IVInhibitor[2]
Carbonic anhydrase IXInhibitor[2]
Carbonic anhydrase VIInhibitor[2]
Carbonic anhydrase XIIInhibitor[2]
Carbonic anhydrase XIVInhibitor[2]
Ref 1Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. To Reference
Ref 2J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. To Reference



 

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