Therapeutic Targets Database
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TTD Drug ID: DNC010078

Drug Information
NameD-366
IndicationNot AvailableExperimental    
Structure

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InChI1S/C28H36N4O2/c1-2-12-31(23-10-11-24-21(19-23)7-5-9-27(24)33)16-1
3-30-14-17-32(18-15-30)28(34)26-20-22-6-3-4-8-25(22)29-26/h3-9,20
,23,29,33H,2,10-19H2,1H3/t23-/m0/s1
InChIKeyDQMMOHPPKACCQN-QHCPKHFHSA-N
Canonical SMILESCCCN(CCN1CCN(CC1)C(=O)C2=CC3=CC=CC=C3N2)C4CCC5=C(C4)C=CC=C5O    
Isomeric SMILESCCCN(CCN1CCN(CC1)C(=O)C2=CC3=CC=CC=C3N2)[C@H]4CCC5=C(C4)C=CC=C5O
TargetDopamine D2 receptorInhibitor[1]
Dopamine D3 receptorInhibitor[1]
Ref 1J Med Chem. 2010 Feb 11;53(3):1023-37.Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. To Reference



 

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