Therapeutic Targets Database
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TTD Drug ID: DNC010656

Drug Information
NameRo-4938581
IndicationNot AvailableExperimental    
Structure

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InChI1S/C13H8BrF2N5/c14-7-1-2-9-8(3-7)13-17-5-19-21(13)4-10-11(12(15)1
6)18-6-20(9)10/h1-3,5-6,12H,4H2
InChIKeyAFJRYPJIKHMNGL-UHFFFAOYSA-N
Canonical SMILESC1C2=C(N=CN2C3=C(C=C(C=C3)Br)C4=NC=NN41)C(F)F    
TargetGABA receptor alpha-1 subunitInhibitor[1]
GABA receptor alpha-2 subunitInhibitor[1]
GABA receptor alpha-3 subunitInhibitor[1]
GABA receptor alpha-5 subunitInhibitor[1]
GABA receptor beta-3 subunitInhibitor[1]
GABA receptor gamma-2 subunitInhibitor[1]
Ref 1Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. Epub 2009 Aug 15.The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. To Reference



 

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