Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC010833

Drug Information
Name2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole
4-(2-(4-tert-butylphenylthio)ethyl)-1H-imidazole
4-(2-(40-tert-butylphenylthio)ethyl)-1H-imidazole
IndicationNot AvailableExperimental    
Structure

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TargetCytochrome P450 2D6Inhibitor[1]
Cytochrome P450 3A4Inhibitor[1]
Histamine H3 receptorInhibitor[2]
Histamine H4 receptorInhibitor[3]
Ref 1J Med Chem. 2010 May 13;53(9):3840-4.Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice. To Reference
Ref 2J Med Chem. 2010 Sep 9;53(17):6445-56.Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain. To Reference
Ref 3Bioorg. Med. Chem. 18(14):5441-5448 (2010) To Reference



 

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