Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DPR000053

Drug Information
NameGNTI
SynonymsG 3416; G3416_SIGMA; CID9853099; GNTI di-trifluoroacetate; SMR001338894; 5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate; Guanidinyl-naltrindole di-trifluoroacetate; NCGC00093944-01; 5'-Guanidinylnaltrindole dihydrochloride; EU-0100559; GNTI; MLS002320748
CompanyUniversity of Minneapolis
IndicationObesity
[ICD9: 278   ICD10: E66]
Preclinical    [1]
Structure

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InChI1S/C27H29N5O3.ClH/c28-25(29)30-15-4-5-18-16(10-15)17-11-27(34)20-
9-14-3-6-19(33)23-21(14)26(27,24(35-23)22(17)31-18)7-8-32(20)12-1
3-1-2-13;/h3-6,10,13,20,24,31,33-34H,1-2,7-9,11-12H2,(H4,28,29,30
);1H/t20-,24?,26+,27-;/m1./s1
InChIKeyVNPAGZLSOUNWEV-DXZXNDDESA-N
Canonical SMILESC1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C=CC(=C8)N=C(N)
N.Cl    
Isomeric SMILESC1CC1CN2CC[C@]34C5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C=CC
(=C8)N=C(N)N.Cl
CAS NumberCAS 219655-56-8
PubChem Compound IDCID 44246743.
PubChem Substance IDSID 85273837.
TargetKappa-type opioid receptor Antagonist[1]
Mu-type opioid receptor Antagonist[1]
Ref 1Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. To Reference



 

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