Therapeutic Targets Database
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TTD Drug ID: DPR000154

Drug Information
NameSB-639
Synonyms(E)-N-hydroxy-3-[2-phenethyl-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamide; CHEBI:557921; AC1OCG09; CID6918877; SB-639; CHEMBL491316
CompanyGlaxoSmithKline
IndicationCancers
[ICD9: 140-229   ICD10: C00-C96]
Preclinical    
Structure

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InChI1S/C24H28N4O2/c29-24(26-30)13-10-20-8-11-22-21(18-20)25-23(12-9-1
9-6-2-1-3-7-19)28(22)17-16-27-14-4-5-15-27/h1-3,6-8,10-11,13,18,3
0H,4-5,9,12,14-17H2,(H,26,29)/b13-10+
InChIKeyRCDIZKAYZBEALO-JLHYYAGUSA-N
Canonical SMILESC1CCN(C1)CCN2C3=C(C=C(C=C3)C=CC(=O)NO)N=C2CCC4=CC=CC=C4    
Isomeric SMILESC1CCN(C1)CCN2C3=C(C=C(C=C3)/C=C/C(=O)NO)N=C2CCC4=CC=CC=C4
Therapeutic ClassCancer
PubChem Compound IDCID 6918877.
PubChem Substance IDSID 12015994.
TargetHistone deacetylaseInhibitor[1]
Ref 1Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. To Reference



 

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