Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDC00013

Target Information
NamePlasma kallikrein    
Type of targetSuccessful target    
SynonymsFletcher factor    
KLK3    
KLKB1    
Kininogenin    
Plasma kallikrein heavy chain    
Plasma kallikrein light chain    
Plasma prekallikrein    
DiseaseHereditary Angioedema (HAE)
[ICD9: 277.6   ICD10: D84.1]
[1][2][3]
Drug(s)EcallantideApprovedHereditary angioedema[4][1][2][3]
EC NumberEC 3.4.21.34
PathwayComplement and coagulation cascades
UniProt IDP03952
PDB Structure2ANW; 2ANY.    
SequenceMILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD MRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
Target ValidationClick to Find Target Validation Information.    
Inhibitor (3,4-dichlorophenyl)[5]
(3-nitro-1H-pyrazol-1-yl)[5]
(3-nitro-1H-pyrazol-1-yl)[5]
(4-bromo-1H-pyrazol-1-yl)[5]
1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide[5]
D-Pro-Phe-Arg chloromethyl ketone[6]
Ecallantide[4][1][2][3]
ZK-810388[7]
ZK-813039[7]
ZK-814048[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Current and emerging management options for hereditary angioedema in the US. Drugs. 2008;68(18):2561-73. doi: 10.2165/0003495-200868180-00003. To Reference
Ref 2Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther. 2008 Aug;8(8):1187-99. To Reference
Ref 3Successful resolution of bowel obstruction in a patient with hereditary angioedema. Eur J Gastroenterol Hepatol. 2008 Jun;20(6):583-7. To Reference
Ref 4Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. To Reference
Ref 5J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. To Reference
Ref 6J Med Chem. 2008 Jun 12;51(11):3077-80. Epub 2008 May 7.Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. To Reference
Ref 7J Med Chem. 2007 Jun 28;50(13):2967-80. Epub 2007 May 31.Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543