Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDC00014

Target Information
NameGlucosylceramidase    
Type of targetClinical trial target    
SynonymsAcid beta-glucosidase    
Alglucerase    
Beta-glucocerebrosidase    
D-glucosyl-N-acylsphingosine glucohydrolase    
Imiglucerase    
DiseaseMetabolic Disease
[ICD9: 270-279   ICD10: E70-E89]
[1][2]
Drug(s)Isofagomine tartratePhase IIMetabolic Disease[1][2]
EC NumberEC 3.2.1.45
PathwayLysosome
Metabolic pathways
Other glycan degradation
Sphingolipid metabolism
UniProt IDP04062
PDB Structure1OGS; 1Y7V; 2F61; 2J25; 2NSX; 2NT0; 2NT1; 2V3D; 2V3E; 2V3F; 2VT0; 2WCG; 2WKL; 2XWD; 2XWE; 3GXD; 3GXF; 3GXI; 3GXM; 3KE0; 3KEH; 3RIK; 3RIL.    
SequenceMEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Target ValidationClick to Find Target Validation Information.    
Inhibitor (2R,3S,4S,5R)-2-hexylpiperidine-3,4,5-triol[3]
(2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol[3]
(2R,3S,4S,5R)-2-propylpiperidine-3,4,5-triol[3]
1,5-Dideoxy-1,5-imino-D-xylitol[4]
2- (Acetylamino)-2-Deoxy-a-D-Glucopyranose[5]
ISOFAGOMINE[4]
Isofagomine tartrate[1][2]
L-Isofagomine[4]
Myo-Inositol[5]
N- (Propylamide-acetophenone)-1-deoxynojirimycin[6]
N- (Propylamide-benzophenone)-1-deoxynojirimycin[6]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem. 2008 Nov 3;9(16):2650-62. To Reference
Ref 2Isofagomine induced stabilization of glucocerebrosidase. Chembiochem. 2008 Nov 3;9(16):2643-9. To Reference
Ref 3Bioorg Med Chem. 2010 Apr 1;18(7):2645-50. Epub 2010 Feb 20.Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. To Reference
Ref 4Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. Epub 2008 Jun 18.In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. To Reference
Ref 5Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 6Bioorg Med Chem. 2010 Jan 1;18(1):267-73. Epub 2009 Oct 31.Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. To Reference



 

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