Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDC00087

Target Information
NameHigh affinity interleukin-8 receptor B    
Type of targetClinical trial target    
GRO/MGSA receptor    
IL-8 receptor type 2    
IL-8R B    
Interleukin-8 receptor B    
DiseaseAcute respiratory distress syndrome
[ICD9: 518.5, 518.82   ICD10: J80]
[ICD9: 493   ICD10: J45]
Chronic Obstructive Pulmonary Disease (COPD)
[ICD9: 490-492, 494-496   ICD10: J40-J44, J47]
Colorectal cancer
[ICD9: 153, 154   ICD10: C18-C21]
Lung injury[1]
Drug(s)ReparixinPhase II completedIschemia-Reperfusion Injury; Lung Transplantation; Graft rejection in heart transplantation[4]
AZD5069Phase IIAsthma
SB-656933Phase IIChronic obstructive pulmonary disease[5]
SB-656933Phase IICystic fibrosis & COPD[6]
SCH-527123Phase IIChronic obstructive pulmonary disease[7]
PS-938285Phase I completedChronic Obstructive Pulmonary Disease[2]
1325756Phase ICOPD
SB-265610Discontinued in Phase IChronic obstructive pulmonary disease[5]
BioChemical ClassG-protein coupled receptor (rhodopsin family)    
PathwayChemokine signaling pathway
Cytokine-cytokine receptor interaction
Epithelial cell signaling in Helicobacter pylori
UniProt IDP25025
FunctionReceptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of il-8 to the receptor causes activation of neutrophils. This response is mediated via a g-protein that activate a phosphatidylinositol-calcium second messenger system.    
Target ValidationClick to Find Target Validation Information.    
Inhibitor (R)-2-[8]
1- (2-Hydroxy-3-nitro-phenyl)-3-phenyl-urea[9]
1- (2-Hydroxy-5-nitro-phenyl)-3-phenyl-urea[9]
1- (2-bromophenyl)-3-[10]
1- (2-hydroxy-4-nitrophenyl)-3-phenylurea[10]
1- (3-cyano-2-hydroxyphenyl)-3-phenylurea[10]
1- (4-cyano-2-hydroxyphenyl)-3-phenylurea[10]
1- (5-chloro-2-hydroxy-4-nitrophenyl)-3-phenylurea[10]
2- (3-Isobutyl-phenyl)-propionic acid[8]
2- (3-Isopropyl-phenyl)-propionic acid[8]
2-[3- (1-Hydroxy-propyl)-phenyl]-propionic acid[8]
2-[3- (1-Phenyl-ethyl)-phenyl]-propionic acid[8]
2-[3- (2-Methyl-butyl)-phenyl]-propionic acid[8]
5- (pentylthio)thiazolo[4,5-d]pyrimidin-7-ol[11]
AgonistIl-8 ([12]
AntagonistN- (3-[13]
SB 225002[1]
SB 265610[1]
SB 272844[14]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Interleukin-8 receptor antagonists in pulmonary diseases. Curr Opin Pharmacol. 2001 Jun;1(3):242-7. To Reference
Ref 2CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. To Reference
Ref 3Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem. 2003 Mar 7;278(10):8508-15. Epub 2002 Dec 20. To Reference
Ref 4New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. To Reference
Ref 5Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. To Reference
Ref 6GSK. Product Development Pipeline. February 2009. To Reference
Ref 7Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. To Reference
Ref 8J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. To Reference
Ref 9J Med Chem. 2004 Mar 11;47(6):1319-21.Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. To Reference
Ref 10Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. Epub 2006 Dec 23.Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. To Reference
Ref 11Bioorg Med Chem Lett. 2006 Feb 15;16(4):960-3. Epub 2005 Nov 15.Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists. To Reference
Ref 12Il-8((3-73))K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2. Biochem Biophys Res Commun. 2001 Aug 24;286(3):595-600. To Reference
Ref 13A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002 Dec 1;169(11):6435-44. To Reference
Ref 14The selective CXCR2 antagonist SB272844 blocks interleukin-8 and growth-related oncogene-alpha-mediated inhibition of spontaneous neutrophil apoptosis. Pulm Pharmacol Ther. 2002;15(2):103-10. To Reference


Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.

Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543