Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDC00098

Target Information
Type of targetClinical trial target    
CD62E antigen    
Endothelial leukocyte adhesion molecule 1    
Leukocyte-endothelial cell adhesion molecule 2    
[ICD9: 493   ICD10: J45]
Atopic Dermatitis
[ICD9: 691.8   ICD10: L20]
Chronic Obstructive Pulmonary Disease (COPD)
[ICD9: 490-492, 494-496   ICD10: J40-J44, J47]
Inflammatory skin disorder[4]
Ischemic stroke
[ICD9: 434.91   ICD10: I61-I63]
Psoriasis and Psoriatic Disorders
[ICD9: 696   ICD10: L40]
Drug(s)BimosiamosePhase IIa completedPsoriasis and Psoriatic Disorders, Atopic Dermatitis[1][2][3]
BimosiamosePhase IIaChronic Obstructive Pulmonary Disease[1][2][3]
BimosiamosePhase IIAsthma[1][2][3]
BimosiamosePhase IIInflammatory Disorders[1][2][3]
BioChemical ClassGrowth factor    
PathwayCell adhesion molecules (CAMs)
UniProt IDP16581
PDB Structure1ESL; 1G1T; 1KJA.    
FunctionExpressed on cytokine induced endothelial cells and mediates their binding to leukocytes. The ligand recognized by elam-1 is sialyl-lewis x (alpha(1->3)fucosylated derivatives of polylactosamine that are found at the nonreducing termini of glycolipids).    
Target ValidationClick to Find Target Validation Information.    
Efomycine M[4]
O-Sialic Acid[7]
AntibodyMonoclonal antibodies[4]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. Shock. 2008 Apr;29(4):475-82. To Reference
Ref 2The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers. Biopharm Drug Dispos. 2007 Dec;28(9):475-84. To Reference
Ref 3Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial. Pulm Pharmacol Ther. 2006;19(4):233-41. Epub 2005 Sep 1. To Reference
Ref 4Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders? Trends Pharmacol Sci. 2003 Feb;24(2):49-52. To Reference
Ref 5Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex. Stroke. 1995 Sep;26(9):1665-8; discussion 1668-9. To Reference
Ref 6Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 7Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. To Reference


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