Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDC00181

Target Information
NameProtein kinase C    
Type of targetClinical trial target    
DiseaseAmyotrophic lateral sclerosis
[ICD9: 335.20   ICD10: G12.2]
Cancer, unspecific
[ICD9: 140-229   ICD10: C00-C96]
Proteinuria-induced tubular injury[3]
Vascular disease
[ICD9: 325, 430-459   ICD10: G45-G46, I60-I95]
Drug(s)HO-0303Phase II/IIIDiabetic foot ulcers
AEB07Phase IITransplant therapeutics[5]
AEB071Phase IIPsoriasis
RottlerinPreclinicalParkinsoní»s Disease[6]
EC NumberEC 2.7.1.-
Related US Patent6,306,383
Target ValidationClick to Find Target Validation Information.    
Calphostin C[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C. Neurobiol Dis. 2000 Aug;7(4):375-83. To Reference
Ref 2Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001;40(1):55-63. To Reference
Ref 3Fatty acids carried on albumin modulate proximal tubular cell fibronectin production: a role for protein kinase C. Nephrol Dial Transplant. 2002 Oct;17(10):1751-7. To Reference
Ref 4Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000;5(3):173-85. To Reference
Ref 5What's next in the pipeline. Am J Transplant. 2008 Oct;8(10):1972-81. To Reference
Ref 6Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. To Reference
Ref 7Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. To Reference
Ref 8Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery. 2001 Aug;130(2):310-8. To Reference
Ref 9The protein kinase C inhibitor G?6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res. 2003 Jan 1;63(1):31-5. To Reference


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