Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDC00205

Target Information
NameGlucagon-like peptide 1    
Type of targetSuccessful target    
SynonymsGLP    
GLP-1    
Glucagon-like peptide-1(7-36)-amide    
DiseaseAlzheimer's disease
[ICD9: 331.0   ICD10: G30]
[1]
Obesity
[ICD9: 278   ICD10: E66]
[2]
Drug(s)AVE0010Phase IIIT2 diabetes[3]
AlbiglutidePhase IIIType 2 diabetes[4]
CJC-1134-PCPhase IIType 2 diabetes
Lixisenatide + LantusPhase IIFixed-Ratio / Type 2 diabetes
RG7685Phase IIType 2 diabetes
2374697Phase IObesity
LixisenatideRegistrationType 2 diabetes
Lixisenatide + LantusPhase IFix-Flex / Type 2 diabetes
NN9926Phase IType 2 diabetes
RG7697Phase IType 2 diabetes
VRS-859Phase IType 2 diabetes
UniProt IDP41521
SequenceHAEGTYTSDVSSYLQDQAAKEFVSWLKTGR
Target ValidationClick to Find Target Validation Information.    
ActivatorAVE0010[3]
Albiglutide[4]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003 Jun 1;72(5):603-12. To Reference
Ref 2Promising new approaches to the management of obesity. Drugs. 2000 Jul;60(1):1-9. To Reference
Ref 3Pharma & Vaccines. Product Development Pipeline. April 29 2009. To Reference
Ref 4GSK. Product Development Pipeline. February 2009. To Reference



 

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