Therapeutic Targets Database
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TTD Target ID: TTDC00304

Target Information
NameSodium-dependent noradrenaline transporter    
Type of targetSuccessful target    
SynonymsNET    
Norepinephrine transporter    
DiseaseDepression
[ICD9: 311   ICD10: F32]
[1]
Drug(s)Milnacipran HClApprovedFibromyalgia[2]
NERI IVPhase IISevere Mood Disorders[3]
EsreboxetineDiscontinuedFibromyalgia[4]
LY367265DiscontinuedDepression[5]
BioChemical ClassTransmembrane protein    
UniProt IDP23975
FunctionAmine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.    
SequenceMLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL VAQRDIRQFQLQHWLAI
Target ValidationClick to Find Target Validation Information.    
Inhibitor ([6]
(+/-)-3-[7]
(2S,3S)-2-[8]
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol[8]
(R)-1-[9]
(R)-2-[10]
(R)-3-[7]
(R)-6-[7]
(R)-DULOXETINE[11]
(R)-N-isobutyl-N-[12]
(R)-N-isopropyl-N-[12]
(R)-Norfluoxetine[13]
(S)-3-[7]
(S)-6-[7]
(S)-N-isobutyl-N-[12]
(S)-NORDULOXETINE[11]
(S)-Norfluoxetine[13]
(S,S)-reboxetine[14]
1- (1,2-diphenylethyl)piperazine[15]
1- (1,4-diphenylbutan-2-yl)piperazine[16]
1- (1-[10]
1- (1-[10]
1- (1-phenyl-2-[10]
1- (1-phenyl-2-o-tolylethyl)piperazine[15]
1- (2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine[17]
1- (2-[18]
1- (2-[10]
1- (2-[15]
1- (2-[19]
1- (2-[15]
1- (2-[15]
1- (2-[15]
1- (2-[18]
1- (2-[10]
1- (2-[15]
1- (2-[18]
1- (2-[15]
1- (2-[18]
1- (2-[7]
1- (2-[18]
1- (2-[18]
1- (2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1- (2-phenoxyphenyl)piperazine[18]
1- (3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol[21]
1- (3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol[21]
1- (3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane[22]
1- (3-bromophenyl)-2-[23]
1- (3-chlorophenyl)-2-[23]
1- (3-chlorophenyl)-2-[23]
1- (3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1- (3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1- (4-bromophenyl)-2-[23]
1- (4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1- (4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1- (4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1- (4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one[20]
1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one[20]
1S,2R-milnacipran[24]
2- ([25]
2- ([25]
2- (2'-Aminoethyl)-5-benzyltetrahydrofuran[26]
2- (2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine[17]
2- (2-chlorophenoxy)-3-[19]
2- (2-fluorophenoxy)-3-[19]
2- (2-methoxyphenoxy)-3-[19]
2- (2-phenyl-2-[15]
2- (Aminomethyl)-5-[26]
2- (Aminomethyl)-5-[26]
2- (Aminomethyl)-5-[26]
2- (Aminomethyl)-5-phenethyltetrahydrofuran[26]
2- (N,N-Diethylamino)-3'-chloropropiophenone[27]
2- (N-Cyclopentylamino)-3'-bromopropiophenone[23]
2- (N-Cyclopentylamino)-3'-chloropropiophenone[27]
2- (N-Cyclopentylamino)-3'-fluoropropiophenone[23]
2- (N-Cyclopentylamino)-3'-methoxypropiophenone[23]
2- (N-Cyclopentylamino)-3'-methylpropiophenone[23]
2- (N-Cyclopropylamino)-3-chloropropiophenone[27]
2- (N-Pyrrolidinyl)-3'-bromopropiophenone[23]
2- (N-Pyrrolidinyl)-3'-fluoropropiophenone[23]
2- (N-Pyrrolidinyl)-3'-methoxypropiophenone[23]
2- (N-Pyrrolidinyl)-3'-methylpropiophenone[23]
2- (N-Pyrrolidinyl)-3'-nitropropiophenone[23]
2- (N-tert-Butylamino)-3',4'-dichloropropiophenone[27]
2- (N-tert-Butylamino)-3'-chloroheptanophenone[27]
2- (N-tert-Butylamino)-3'-chlorohexanophenone[27]
2- (N-tert-Butylamino)-3'-chlorooctanophenone[27]
2- (N-tert-Butylamino)-3'-chloropentanophenone[27]
2- (N-tert-Butylamino)propiophenone[27]
2- (tert-Butylamino)-3',4'-dichlorobutyrophenone[27]
2- (tert-Butylamino)-3',4'-dichloropentanophenone[27]
2- (tert-butylamino)-1-[23]
2- (tert-butylamino)-1-m-tolylpropan-1-one[23]
2- (tert-butylamino)-1-p-tolylpropan-1-one[23]
2-Amino-1- (4-methylthiophenyl)propane[28]
2-Aminomethyl-5- (p-bromophenyl)tetrahydrofuran[26]
2-Aminomethyl-5- (p-chlorophenyl)tetrahydrofuran[26]
2-Aminomethyl-5- (p-methoxyphenyl)tetrahydrofuran[26]
2-Aminomethyl-5- (p-t-butylphenyl)tetrahydrofuran[26]
2-Aminomethyl-5- (phenyl)tetrahydrofuran[26]
2-phenoxy-3- (piperidin-4-yl)pyridine[19]
2pyrrolidin-1-yl-1-phenylpentan-1-one[20]
3- (1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine[29]
3- (2-phenyl-2-[15]
3- (2-phenyl-2-[15]
3- (3'-furyl)-aniline[30]
3- (piperidin-4-yl)-2-[19]
3-p-Tolyl-8-aza-bicyclo[3.2.1]octane[31]
3alpha- (bis-chloro-phenylmethoxy)tropane[32]
4- ([7]
4- (1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine[33]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-[18]
4- (2-fluoro-6-[19]
4- (2-fluoro-6-[18]
4- (2-fluoro-6-[18]
4- (2-fluoro-6-phenoxyphenyl)piperidine[18]
4- (2-phenoxyphenyl)piperidine[18]
4- (3'-furyl)-aniline[30]
4- (3-fluoro-2-phenoxyphenyl)piperidine[18]
4- (4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one[34]
6- (piperidin-4-ylmethoxy)-2-naphthonitrile[7]
7- (piperidin-4-ylmethoxy)-2-naphthonitrile[7]
8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane[31]
AMIFLAMINE[17]
Biphenyl-2-ylmethyl- (S)-pyrrolidin-3-yl-amine[35]
D-166A[36]
D-211A[36]
D-211B[36]
D-254C[36]
D-257A[36]
D-257C[36]
DIFLUOROBENZTROPINE[32]
KF-A5[37]
LITOXETINE[12]
LY367265[5]
MDL-28618[6]
METHYLENEDIOXYAMPHETAMINE[38]
METHYLENEDIOXYMETHAMPHETAMINE[28]
Milnacipran HCl[2]
N,N-dimethyl (2-phenoxyphenyl)methanamine[39]
N- (2-oxazolemethyl)milnacipran[40]
N-benzyl-N-isobutylpiperidin-4-amine[41]
NISOXETINE[42]
PF-18298,   PF-184298[10]
PF-3409409[43]
PF-526014[10]
POLYGALATENOSIDE B[44]
PYROVALERONE[20]
R-NORDULOXETINE[11]
RTI-219[45]
S-34324[46]
S33005[5]
WAY-256805[47]
WIN-35065-2[48]
WIN-35066-2[49]
WIN_35428[48]
[3- (3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine[21]
cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine[50]
isobutyl- (4-methyl-benzyl)-piperidin-4-yl-amine[41]
para-chloroamphetamine[28]
trans-3- (o-tolyloxy)-2,3-dihydro-1H-inden-1-amine[50]
{2-[3- (Phenylsulfonyl)-1H-indol-4-yl]ethyl}amine[51]
BlockerEsreboxetine[4]
NERI IV[3]
Oxaprotiline[52]
Modulator3,4-Methylenedioxymethamphetamine[53]
MMDA[54]
MultitargetMilnacipran HCl[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
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Professor in Department of Pharmacy
National University of Singapore, Singapore


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