TTD Target ID: TTDC00338

Target Information
Name	Activin receptor-like kinase-1
Type of target	Clinical trial target
Synonyms	ACVRL1
	ACVRLK1
	ALK-1
	Activin receptor-like kinase 1
	SKR3
	Serine/threonine-protein kinase receptor R3
	TGF-B superfamily receptor type I
	TSR-I
Disease	Advanced cancers, age-related macular degeneration [ICD9: 140-229, 362.50   ICD10: C00-C96, H35.3]				[1]
Drug(s)	ACE-041		Phase I	Advanced cancers, age-related macular degeneration	[1]
	PF-03446962		Phase I	Solid Tumors
UniProt ID	P37023
PDB Structure	3MY0.
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Sequence	MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL TALRIKKTLQKISNSPEKPKVIQ
Inhibitor	ACE-041		[1]
Cross References	3D Structure Related Literature On-Line Medical Dictionary
Ref 1	2011 Pipeline of Acceleron Pharma. To Reference

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Professor in Department of Pharmacy
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