Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00033

Target Information
NameAldo-keto reductase family 1 member C3    
Type of targetResearch target    
Synonyms3-alpha-hydroxysteroid dehydrogenase    
Chlordecone reductase homolog HAKRb    
Dihydrodiol dehydrogenase 3    
Dihydrodiol dehydrogenase, type I    
Human prostaglandin F synthase    
Prostaglandin F synthase    
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase    
DiseaseCancer, unspecific
[ICD9: 140-229   ICD10: C00-C96]
Head and neck cancer
[ICD9: 140-149   ICD10: C07-C14, C32-C33]
BioChemical ClassOxidoreductases acting on the CH-OH group of donors    
EC NumberEC 1.1.1.-
PathwayArachidonic acid metabolism
Metabolism of xenobiotics by cytochrome P450
UniProt IDP42330
PDB Structure1RY0; 1RY8; 1S1P; 1S1R; 1S2A; 1S2C; 1XF0; 1ZQ5.    
FunctionCatalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (pg) d2, pgh2 and phenanthrenequinone (pq) and the oxidation of 9alpha,11beta- pgf2 to pgd2.    
Target ValidationClick to Find Target Validation Information.    
Inhibitor2'-Monophosphoadenosine 5'-Diphosphoribose[3]
2- (4-Chlorobenzylidene)cyclopentanone[4]
2- (4-chlorobenzylidene)cyclopentyl ethyl ether[4]
2- (4-chlorobenzylidene)cyclopentylmethyl ether[4]
2-[ (2,2-diphenylacetyl)amino]benzoic acid[5]
3-Bromo-5-phenylsalicylc acid[6]
3-Phenylcyclopentanecarboxylic acid[4]
Acetate Ion[3]
Flufenamic Acid[9]
M-Phenoxybenzoic Acid For Cis-Isomer[5]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res. 2004 Mar 1;64(5):1802-10. To Reference
Ref 2Preferential expression of hPGFS in primary SCCHN and tumour cell lines derived from respiratory and digestive organs. Br J Cancer. 2004 Mar 8;90(5):1093-9. To Reference
Ref 3Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 4Eur J Med Chem. 2009 Jun;44(6):2563-71. Epub 2009 Feb 5.New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. To Reference
Ref 5Bioorg Med Chem Lett. 2005 Dec 1;15(23):5170-5. Epub 2005 Sep 23.Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents. To Reference
Ref 6J Med Chem. 2009 May 28;52(10):3259-64.Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). To Reference
Ref 7Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. To Reference
Ref 8J Biol Chem. 2007 Mar 16;282(11):8368-79. Epub 2006 Dec 13.Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. To Reference
Ref 9Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51. To Reference


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