Therapeutic Targets Database
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TTD Target ID: TTDR00037

Target Information
NameScytalone dehydratase    
Type of targetResearch target    
DiseaseFungal diseases
[ICD9: 110-118   ICD10: B35-B49]
[1]
BioChemical ClassCarbon-oxygen lyases    
UniProt IDP56221
PDB Structure1IDP; 1STD; 2STD; 3STD; 4STD; 5STD; 6STD; 7STD.    
FunctionCatalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.    
SequenceMGSQVQKSDEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLWEA MPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRVPHQRYKDTTMKE VTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDFDRIFEDGRETFGDK
Target ValidationClick to Find Target Validation Information.    
Inhibitor (3-Phenyl-propyl)-quinazolin-4-yl-amine[2]
2-Hydroxy-N- (3-phenyl-propyl)-benzamide[2]
5-Fluoro-2-hydroxy-N-isopropyl-benzamide[3]
Carpropamid[1]
Isoquinolin-1-yl- (3-phenyl-propyl)-amine[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus. Biosci Biotechnol Biochem. 2004 Mar;68(3):615-21. To Reference
Ref 2Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993) To Reference
Ref 3Bioorg Med Chem Lett. 2000 Jan 3;10(1):23-6.Binding dynamics of two water molecules constrained within the scytalone dehydratase binding pocket. To Reference



 

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