TTD Target ID: TTDR00042

Target Information
Name	Beta-hydroxyacyl-acp dehydratase
Type of target	Research target
Synonyms	FabZ
Disease	Malaria [ICD9: 084   ICD10: B50-B54]				[1]
BioChemical Class	Carbon-oxygen lyases
EC Number	EC 4.2.1.-
Pathway	Fatty acid biosynthesis
	Metabolic pathways
UniProt ID	Q8I6T4
Sequence	MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDV SSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGL KQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWK KPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
Target Validation	Click to Find Target Validation Information.
Inhibitor	(-)-CATECHINGALLATE		[2]
	2-Hexadecynoic acid		[3]
	BIOCHANIN		[2]
	EPICATECHIN GALLATE		[2]
	EPIGALOCATECHIN GALLATE		[2]
	FISETIN		[2]
	GALLOCATECHIN GALLATE		[2]
	MORIN		[2]
Cross References	3D Structure Related Literature On-Line Medical Dictionary
Ref 1	Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem. 2003 Nov 14;278(46):45661-71. Epub 2003 Aug 20. To Reference
Ref 2	J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. To Reference
Ref 3	Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. To Reference

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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