Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00070

Target Information
NameCysteine protease    
Type of targetResearch target    
DiseaseChagas' disease
[ICD9: 086   ICD10: B57]
[1]
Related US Patent6,329,377
6,342,531
6,468,977
6,500,802
6,569,847
Target ValidationClick to Find Target Validation Information.    
InhibitorALLICIN[2]
K-777[3]
MELARSOPROL[4]
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi)[1]
S-benzyl phenylmethanesulfinothioate[2]
S-hexyl hexane-1-sulfinothioate[2]
S-isopentyl 3-methylbutane-1-sulfinothioate[2]
S-propyl propane-1-sulfinothioate[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. Epub 2007 Aug 13. To Reference
Ref 2Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. To Reference
Ref 3Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. Epub 2009 Sep 3.Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. To Reference
Ref 4J Med Chem. 2009 Sep 24;52(18):5662-72.On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. To Reference



 

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