Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00142

Target Information
NameDNA topoisomerase    
Type of targetResearch target    
DiseaseCancer, unspecific
[ICD9: 140-229   ICD10: C00-C96]
EC NumberEC
Target ValidationClick to Find Target Validation Information.    
Inhibitor2-Amino-6- (indan-5-ylamino)-3H-pyrimidin-4-one[2]
3- (9-Acridinylamino)-5-[1]
6- (3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione[3]
6- (3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione[3]
6- (3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione[3]
6- (Indan-5-ylamino)-1H-pyrimidine-2,4-dione[3]
6- (Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9. To Reference
Ref 2J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. To Reference
Ref 3J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. To Reference
Ref 4J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. To Reference


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