Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00289

Target Information
NameC-Jun N-terminal kinase    
Type of targetClinical trial target    
SynonymsC-Jun-N-terminal kinase    
JNK    
Mitogen-activated protein kinase    
Stress-activated protein kinase JNK    
DiseaseAlzheimer's disease
[ICD9: 331.0   ICD10: G30]
[1]
Diabetes mellitus
[ICD9: 250   ICD10: E08-E13]
[2]
Rheumatoid arthritis, unspecified
[ICD9: 710-719, 714   ICD10: M00-M25, M05-M06]
[3]
Skin diseases[4]
EC NumberEC 2.7.1.37
Related US Patent6,642,227
InhibitorSP600125[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem. 2001 Apr;77(1):157-64. To Reference
Ref 2JNK: a new therapeutic target for diabetes. Curr Opin Pharmacol. 2003 Aug;3(4):420-5. To Reference
Ref 3c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul;108(1):73-81. To Reference
Ref 4High efficiency of 5-aminolevulinate-photodynamic treatment using UVA irradiation. Carcinogenesis. 2001 Jun;22(6):879-83. To Reference



 

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