Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00289

Target Information
NameC-Jun N-terminal kinase    
Type of targetClinical trial target    
SynonymsC-Jun-N-terminal kinase    
Mitogen-activated protein kinase    
Stress-activated protein kinase JNK    
DiseaseAlzheimer's disease
[ICD9: 331.0   ICD10: G30]
Diabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Rheumatoid arthritis, unspecified
[ICD9: 710-719, 714   ICD10: M00-M25, M05-M06]
Skin diseases[4]
EC NumberEC
Related US Patent6,642,227
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem. 2001 Apr;77(1):157-64. To Reference
Ref 2JNK: a new therapeutic target for diabetes. Curr Opin Pharmacol. 2003 Aug;3(4):420-5. To Reference
Ref 3c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul;108(1):73-81. To Reference
Ref 4High efficiency of 5-aminolevulinate-photodynamic treatment using UVA irradiation. Carcinogenesis. 2001 Jun;22(6):879-83. To Reference


Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.

Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543