Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00348

Target Information
NameNicotinate-nucleotide adenylyltransferase    
Type of targetResearch target    
SynonymsDeamido-NAD(+) diphosphorylase    
Deamido-NAD(+) pyrophosphorylase    
Deamido-NAD(+)Nicotinate-nucleotide adenylyltransferase pyrophosphorylase    
NaMN adenylyltransferase    
Nicotinate mononucleotide adenylyltransferase    
DiseaseBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
[1]
EC NumberEC 2.7.7.18
UniProt IDP52085
PDB Structure1K4K; 1K4M.    
FunctionCatalyzes the reversible adenylation of nicotinate mononucleotide (namn) to nicotinic acid adenine dinucleotide (naad).    
SequenceMKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHML ELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEY ETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNIS ATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
InhibitorDeamido-Nad+[2]
Nicotinamide-Adenine-Dinucleotide[2]
BinderDeamido-NAD[1]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure. 2002 Jan;10(1):69-79. To Reference
Ref 2Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference



 

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