Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00355

Target Information
NamePeptidyl-prolyl cis-trans isomerase NIMA-interacting 1    
Type of targetResearch target    
SynonymsPPIase Pin1    
Peptidyl prolyl cis/trans isomerase Pin1    
Prolyl isomerase Pin1    
Rotamase Pin1    
DiseaseAlzheimer's disease
[ICD9: 331.0   ICD10: G30]
Cancer, unspecific
[ICD9: 140-229   ICD10: C00-C96]
Hepatocellular carcinoma
[ICD9: 155   ICD10: C22.0]
BioChemical ClassCis-trans-Isomerases    
EC NumberEC
UniProt IDQ13526
PDB Structure1F8A; 1I8G; 1I8H; 1NMV; 1PIN; 1ZCN; 2F21.    
FunctionEssential ppiase that regulates mitosis presumably by interacting with nima and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue n-terminal to the isomerized proline bond. Catalyzing pser/thr-pro cis/trans isomerization.    
Target ValidationClick to Find Target Validation Information.    
Inhibitor (R)-2-[4]
Ac-Bth-Thr (PO3H2)-Pip-Nal-Gln-NH2[6]
Ac-Phe-D-Thr (PO3H2)-Pip-Nal-Gln-NH2[6]
Ac-Phe-Thr (PO3H2)-Pip-Nal-Gln-NH2[6]
Beta- (2-Naphthyl)-Alanine[5]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Pin1: a therapeutic target in Alzheimer neurodegeneration. J Mol Neurosci. 2002 Dec;19(3):275-87. To Reference
Ref 2Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J Cell Sci. 2003 Mar 1;116(Pt 5):773-83. To Reference
Ref 3PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. Oncogene. 2004 May 20;23(23):4182-6. To Reference
Ref 4Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II). To Reference
Ref 5Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. To Reference
Ref 6J Med Chem. 2006 Apr 6;49(7):2147-50.Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. To Reference


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