Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00409

Target Information
NameVanilloid receptor    
Type of targetResearch target    
DiseaseAnalgesics
[ICD9: 338   ICD10: R52]
[1]
Pain, unspecified
[ICD9: 338,780   ICD10: R52, G89]
[1]
Skin inflammation[1]
Related US Patent6,476,076
Target ValidationClick to Find Target Validation Information.    
Inhibitor1,3-dibenzyl urea[2]
4-Pyridin-2-yl-piperazine-1-carboxylic acid amide[3]
6'-Iodononivamide[4]
A-795614[5]
AMG-628[6]
ATC-120[7]
CAPSAZEPINE[8]
IODORESINIFERATOXIN[9]
JNJ-17203212[8]
MK-056[7]
N- (4-tert-butylphenyl)-4-[10]
Pyrrolidin-1-yl-thiourea[3]
SC-0030,   SC0030[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin. J Investig Dermatol Symp Proc. 1997 Aug;2(1):56-60. To Reference
Ref 2Eur J Med Chem. 2009 Jan;44(1):432-6. Epub 2007 Dec 28.Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. To Reference
Ref 3Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. To Reference
Ref 4Bioorg Med Chem. 2010 Nov 15;18(22):8092-105. Epub 2010 Sep 18.Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin. To Reference
Ref 5Bioorg Med Chem. 2008 Sep 15;16(18):8516-25. Epub 2008 Aug 7.Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. To Reference
Ref 6J Med Chem. 2007 Jul 26;50(15):3528-39. Epub 2007 Jun 22.Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. To Reference
Ref 7Bioorg Med Chem. 2010 Jan 1;18(1):111-6. Epub 2009 Nov 10.Silicon switch approach in TRPV1 antagonist MK-056 and its analogues. To Reference
Ref 8J Med Chem. 2007 May 31;50(11):2589-96. Epub 2007 May 10.The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. To Reference
Ref 9J Med Chem. 2008 Jan 10;51(1):57-67. Epub 2007 Dec 12.Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. To Reference
Ref 10Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21. Epub 2006 Jul 25.From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. To Reference



 

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