Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00529

Target Information
NameAdenosine kinase    
Type of targetResearch target    
Adenosine 5'-phosphotransferase    
[ICD9: 338   ICD10: R52]
Central and peripheral nervous system diseases
[ICD9: 320-389   ICD10: G00-G99]
[ICD9: 345   ICD10: G40]
Inflammatory bowel disease
[ICD9: 555, 556   ICD10: K50, K51]
Pain, unspecified
[ICD9: 338,780   ICD10: R52, G89]
[ICD9: 130   ICD10: B58]
BioChemical ClassTransferases transferring phosphorus-containing groups    
EC NumberEC
PathwayMetabolic pathways
Purine metabolism
UniProt IDP55263
PDB Structure1BX4; 2I6A; 2I6B.    
FunctionAtp dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.    
Target ValidationClick to Find Target Validation Information.    
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Nonnucleoside inhibitors of adenosine kinase. Curr Pharm Des. 2004;10(10):1093-103. To Reference
Ref 2Adenosine kinase inhibitor GP515 improves experimental colitis in mice. J Pharmacol Exp Ther. 2001 Jan;296(1):99-105. To Reference
Ref 36-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities. Biochem Pharmacol. 2005 May 15;69(10):1409-19. To Reference
Ref 4Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. J Med Chem. 2004 Apr 8;47(8):1987-96. To Reference
Ref 5Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism. Osteoarthritis Cartilage. 2005 Mar;13(3):250-7. To Reference
Ref 6J Med Chem. 2006 Nov 16;49(23):6726-31.Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. To Reference
Ref 7Bioorg Med Chem. 2010 May 15;18(10):3403-12. Epub 2010 Apr 8.Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. To Reference


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