| Target
Information |
| Name | Dipeptidyl-peptidase I |
| Type of target | Research target |
| Synonyms | Cathepsin C |
| Cathepsin J |
| Cysteine protease dipeptidyl peptidase I |
| DPP-I |
| DPPI |
| Dipeptidyl peptidase I |
| Dipeptidyl transferase |
| Disease | Alzheimer's disease
[ICD9: 331.0 ICD10: G30] | [1] |
Sepsis
[ICD9: 995.91 ICD10: A40, A41] | [2] |
| BioChemical Class | Hydrolases acting on peptide bonds (Peptidases) |
| EC Number | EC 3.4.14.1 |
| UniProt ID | P53634 |
| PDB Structure | 1K3B; 2DJF; 2DJG; 3PDF. |
| Function | Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin g and granzymes a and b. Can also activate neuramindase and factor xiii. |
| Sequence | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
| Target Validation | Click to Find Target Validation Information. |
| Inhibitor | (S)-2-amino-N- |  | [3] |
| GNF-PF-5434 | | [4] |
| Cross References |
3D Structure
Related Literature
On-Line
Medical Dictionary |
| Ref 1 | Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. To Reference |
| Ref 2 | Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest. 2004 Feb;113(4):628-34. To Reference |
| Ref 3 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7. Epub 2006 May 2.Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. To Reference |
| Ref 4 | Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. Epub 2008 Feb 7.Substrate optimization for monitoring cathepsin C activity in live cells. To Reference |
