Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00602

Target Information
NameHaemophilus influenzae NadR protein    
Type of targetResearch target    
SynonymsTranscriptional regulator nadR    
[ICD9: 001-139   ICD10: A00-B99]
PathwayMetabolic pathways
Nicotinate and nicotinamide metabolism
UniProt IDP44308
PDB Structure1LW7.    
FunctionNadr is bifunctional; it interacts with pnuc at low internal nad levels, permitting transport of nmn intact into the cell. As nad levels increase within the cell, the affinity of nadr for the operator regions of some genes increases.    
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities. J Biol Chem. 2002 Sep 6;277(36):33291-9. Epub 2002 Jun 14. To Reference
Ref 2Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference


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