Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00657

Target Information
Name3-oxoacyl-[acyl-carrier protein] reductase    
Type of targetResearch target    
Synonyms3-ketoacyl-acyl carrier protein reductase    
Beta-ketoacyl-ACP reductase (FabG)    
DiseaseMalaria
[ICD9: 084   ICD10: B50-B54]
[1]
BioChemical ClassOxidoreductases acting on the CH-OH group of donors    
EC NumberEC 1.1.1.100
UniProt IDP25716
Q965D6
PDB Structure1I01; 1Q7B; 1Q7C; 2CF2.    
SequenceMSVLHRFYLFFLFTKFFHCYKISYVLKNAKLAPNHAIKNINSLNLLSENKKENYYYCGEN KVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSK KEEISEVINKILTEHKNVDILVSNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPIS KRMINNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPG FISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGLS P
Target ValidationClick to Find Target Validation Information.    
Inhibitor (-)-CATECHINGALLATE[2]
2-Hexadecynoic acid[3]
CHRYSIN[2]
EPICATECHIN GALLATE[2]
EPIGALOCATECHIN GALLATE[2]
FISETIN[2]
GALLOCATECHIN GALLATE[2]
ISORHAMNETIN[2]
KAEMPFEROL[2]
MORIN[2]
CofactorNADPH[1]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Biochem Biophys Res Commun. 2003 Mar 28;303(1):387-92. To Reference
Ref 2J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. To Reference
Ref 3Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. To Reference



 

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