Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00879

Target Information
NameSorbitol dehydrogenase    
Type of targetResearch target    
SynonymsL-iditol 2-dehydrogenase    
SDH    
DiseaseDiabetic complications
[ICD9: 250   ICD10: E08-E13]
[1]
Myocardial ischemia
[ICD9: 459.89   ICD10: I99.8]
[2]
BioChemical ClassOxidoreductases acting on the CH-OH group of donors    
EC NumberEC 1.1.1.14
PathwayFructose and mannose metabolism
UniProt IDQ00796
PDB Structure1PL6; 1PL7; 1PL8.    
SequenceMAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGLL GCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
Related US Patent6,414,149
6,544,998
6,602,875
6,660,740
InhibitorCP-470,711[2]
Nicotinamide-Adenine-Dinucleotide[3]
ZOPOLRESTAT[4]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase. Structure. 2003 Sep;11(9):1071-85. To Reference
Ref 2Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. FASEB J. 2003 Dec;17(15):2331-3. Epub 2003 Oct 2. To Reference
Ref 3Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 4J Med Chem. 1991 Jan;34(1):108-22.Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. To Reference



 

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