Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00895

Target Information
NameNH(3)-dependent NAD(+) synthetase    
Type of targetResearch target    
SynonymsDiphosphopyridine nucleotide synthetase    
NAD synthase    
NAD synthetase    
NAD+ synthase    
NAD+ synthetase    
Nicotinamide adenine dinucleotide synthetase    
Nitrogen-regulatory protein    
DiseaseBacillus subtilis infections
[ICD9: 001-139   ICD10: A00-B99]
Bacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
BioChemical ClassLigases forming carbon-nitrogen bonds    
EC NumberEC
PathwayMetabolic pathways
Nicotinate and nicotinamide metabolism
Nitrogen metabolism
UniProt IDP18843
PDB Structure1WXE; 1WXF; 1WXG; 1WXH; 1WXI.    
FunctionThis nad synthase uses nh(3) in preference to glutamine.    
Related US Patent6,500,852
Pyrophosphate 2-[5]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Crystallization of NAD+ synthetase from Bacillus subtilis. Proteins. 1996 Oct;26(2):236-8. To Reference
Ref 2Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem. 2003 Jul 17;46(15):3371-81. To Reference
Ref 3Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase. Protein Expr Purif. 2002 Aug;25(3):547-57. To Reference
Ref 4Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 5Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. To Reference


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