Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR00927

Target Information
NameLymphocyte antigen 96    
Type of targetResearch target    
MD-2 protein    
DiseaseEndotoxin-mediated diseases[1]
PathwayPathogenic Escherichia coli infection
Pathogenic Escherichia coli infection
Toll-like receptor signaling pathway
UniProt IDQ9Y6Y9
PDB Structure1T2Z; 2E56; 2E59; 2Z65; 3FXI; 3ULA; 4G8A.    
FunctionCooperates with tlr4 in the innate immune response to bacterial lipopolysaccharide (lps), and with tlr2 in the response to cell wall components from gram-positive and gram-negative bacteria. Enhances tlr4-dependent activation of nf-kappa-b.    
Inhibitor3-Hydroxy-Myristic Acid[2]
Lauric Acid[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J Biol Chem. 2003 Nov 28;278(48):48313-20. Epub 2003 Sep 5. To Reference
Ref 2Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 3Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. To Reference


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