Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR00930

Target Information
NamePhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform    
Type of targetClinical trial target    
SynonymsP110delta    
PI3-kinase p110 subunit delta    
PI3K    
PI3K delta    
Phosphoinositide 3-kinase delta    
PtdIns-3-kinase p110    
DiseaseInflammatory diseases[1][2]
BioChemical ClassTransferases transferring phosphorus-containing groups    
EC NumberEC 2.7.1.153
PathwayAcute myeloid leukemia
Apoptosis
B cell receptor signaling pathway
Chemokine signaling pathway
Chronic myeloid leukemia
Colorectal cancer
Endometrial cancer
ErbB signaling pathway
Fc epsilon RI signaling pathway
Focal adhesion
Glioma
Inositol phosphate metabolism
Insulin signaling pathway
Jak-STAT signaling pathway
Leukocyte transendothelial migration
Melanoma
Natural killer cell mediated cytotoxicity
Non-small cell lung cancer
Pancreatic cancer
Pathways in cancer
Phosphatidylinositol signaling system
Prostate cancer
Regulation of actin cytoskeleton
Renal cell carcinoma
Small cell lung cancer
T cell receptor signaling pathway
Toll-like receptor signaling pathway
Type II diabetes mellitus
VEGF signaling pathway
mTOR signaling pathway
UniProt IDO00329
SequenceMPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN EALRESWKTKVNWLAHNVSKDNRQ
Related US Patent6,518,277
6,667,300
Target ValidationClick to Find Target Validation Information.    
InhibitorIC87114[1]
IC980033[1]
LY-292223[3]
LY-293646[3]
LY-294002[4]
LY294002[1][5]
Wortmannin[1][5]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Selective role of PI3K delta in neutrophil inflammatory responses. Biochem Biophys Res Commun. 2003 Sep 5;308(4):764-9. To Reference
Ref 2Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood. 2004 May 1;103(9):3448-56. Epub 2004 Jan 29. To Reference
Ref 3Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. To Reference
Ref 4J Med Chem. 2006 Jun 29;49(13):3857-71.Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. To Reference
Ref 5The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009 Jun;9(5):550-9. To Reference



 

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