Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR01073

Target Information
NameRetinoic acid receptor RXR-alpha    
Type of targetResearch target    
DiseaseProstate cancer
[ICD9: 185   ICD10: C61]
BioChemical ClassZinc-finger    
PathwayAdipocytokine signaling pathway
Non-small cell lung cancer
PPAR signaling pathway
Pathways in cancer
Small cell lung cancer
Thyroid cancer
UniProt IDP19793
PDB Structure1BY4; 1DSZ; 1FBY; 1FM6; 1FM9; 1G1U; 1G5Y; 1K74; 1LBD; 1MV9; 1MVC; 1MZN; 1R0N; 1RDT; 1RXR; 1XLS; 1XV9; 1XVP; 1YNW; 2ACL; 2NLL; 2P1T; 2P1U; 2P1V; 2ZXZ; 2ZY0; 3DZU; 3DZY; 3E00; 3E94; 3FAL; 3FC6; 3FUG; 3H0A; 3KWY; 3NSP; 3NSQ; 3OAP; 3OZJ; 3PCU; 3R29; 3R2A; 3R5M; 3UVV.    
FunctionNuclear hormone receptor. Involved in retinoic acid response pathway. Binds 9-cis retinoic acid (9c-ra).    
Target ValidationClick to Find Target Validation Information.    
Inhibitor (5BETA)-PREGNANE-3,20-DIONE[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1RXRalpha: a novel target for prostate cancer. Cancer Biol Ther. 2003 Mar-Apr;2(2):185-6. To Reference
Ref 2Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. To Reference
Ref 3J Med Chem. 2005 Aug 25;48(17):5383-403.Farnesoid X receptor: from structure to potential clinical applications. To Reference


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