Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01100

Target Information
NameDNA (cytosine-5)-methyltransferase 3B    
Type of targetResearch target    
SynonymsDNA MTase HsaIIIB    
DNA methyltransferase 3B    
DNA methyltransferase HsaIIIB    
Dnmt3b    
M.HsaIIIB    
DiseaseBreast cancer
[ICD9: 174, 175   ICD10: C50]
[1]
BioChemical ClassTransferases transferring one-carbon groups    
EC NumberEC 2.1.1.37
PathwayMetabolic pathways
Methionine metabolism
UniProt IDQ9UBC3
PDB Structure3FLG; 3QKJ.    
FunctionRequired for genome wide de novo methylation and is essential for development. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs.    
SequenceMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR HLFAPLKDYFACE
Target ValidationClick to Find Target Validation Information.    
Inhibitor (L-)-S-adenosyl-L-homocysteine[2]
CURCUMIN[3]
NSC-106084[3]
NSC-137546[3]
NSC-138419[3]
NSC-154957[3]
NSC-158324[3]
NSC-319745[3]
NSC-345763[3]
NSC-348926[3]
NSC-401077[3]
NSC-54162[3]
NSC-56071[3]
NSC-57893[3]
NSC-622444[3]
NSC-622445[3]
NSC-623548[3]
S-Adenosylhomocysteine[3]
S-tubercidinylhomocysteine[4]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res. 2003 Oct 1;9(12):4415-22. To Reference
Ref 2Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. Epub 2009 Mar 28.Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. To Reference
Ref 3Bioorg Med Chem. 2010 Jan 15;18(2):822-9. Epub 2009 Nov 27.Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. To Reference
Ref 4Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. Epub 2009 Mar 28.SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. To Reference



 

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