Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01157

Target Information
NameProbable nicotinate-nucleotide adenylyltransferase    
Type of targetResearch target    
SynonymsDeamido-NAD(+) diphosphorylase    
Deamido-NAD(+) pyrophosphorylase    
NaMN AT    
NaMN adenylyltransferase    
NaMN-Atase    
Nicotinate mononucleotide adenylyltransferase    
Nicotinate-nucleotide adenylyltransferase    
Nicotinic acid mononucleotide adenylyltransferase    
DiseaseBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
[1]
BioChemical ClassTransferases transferring phosphorus-containing groups    
EC NumberEC 2.7.7.18
PathwayMetabolic pathways
Nicotinate and nicotinamide metabolism
UniProt IDQ9HX21
PDB Structure1YUL; 1YUM; 1YUN.    
FunctionCatalyzes the reversible adenylation of nicotinate mononucleotide (namn) to nicotinic acid adenine dinucleotide (naad) (by similarity).    
SequenceMGKRIGLFGGTFDPVHIGHMRSAVEMAEQFALDELRLLPNARPPHRETPQVSAAQRLAMV ERAVAGVERLTVDPRELQRDKPSYTIDTLESVRAELAADDQLFMLIGWDAFCGLPTWHRW EALLDHCHIVVLQRPDADSEPPESLRDLLAARSVADPQALKGPGGQITFVWQTPLAVSAT QIRALLGAGRSVRFLVPDAVLNYIEAHHLYRAPH
InhibitorDeamido-Nad+[2]
Nicotinamide-Adenine-Dinucleotide[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Crystallization and preliminary X-ray crystallographic analysis of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa. Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):948-9. Epub 2004 Apr 21. To Reference
Ref 2Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference



 

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