Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01183

Target Information
Name3-oxo-5-alpha-steroid 4-dehydrogenase 2    
Type of targetResearch target    
Synonyms5 alpha-SR2    
5-alpha reductase 2    
SR type 2    
Steroid 5-alpha-reductase 2    
Type 2 steroid 5alpha-reductase (5alpha-R)    
DiseaseAlopecia, unspecified
[ICD9: 704.09   ICD10: L65.9]
[1]
Androgen-dependent diseases[2]
Benign prostate hyperplasia
[ICD9: 600   ICD10: N40]
[1]
Prostate cancer
[ICD9: 185   ICD10: C61]
[1]
BioChemical ClassOxidoreductases acting on the CH-CH group of donors    
EC NumberEC 1.3.99.5
PathwayAndrogen and estrogen metabolism
Prostate cancer
UniProt IDP31213
FunctionConverts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.    
SequenceMQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE DYPKSRKALIPFIF
Related US Patent6,355,649
6,552,034
6,555,549
Target ValidationClick to Find Target Validation Information.    
Inhibitor (3-fluoro-4-[3]
(3-methyl-4-[3]
(E)-3-[3]
19-nor-10-azasteroid skeleton[4]
2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol[5]
3-[4- (4-phenoxybenzoyl)phenyl]propanoic acid[3]
4,4'-dihydroxyoctafluoroazobenzene[5]
4- (4-phenoxybenzoyl)benzoic acid[3]
4- (4-phenoxybenzoyl)phenylacetic acid[3]
4-[3- (benzyloxy)benzoyl]benzoic acid[3]
4-[4- (benzhydryloxy)benzoyl]benzoic acid[3]
4-[4- (benzoylamino)benzoyl]benzoic acid[3]
4-[4- (benzylamino)benzoyl]benzoic acid[3]
4-[4-benzyloxy)benzoyl]benzoic acid[3]
FK-143[6]
ONO-3805[6]
{4-[4- (4-bromophenoxy)benzoyl]phenyl}acetic acid[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Clinical application of 5alpha-reductase inhibitors. J Endocrinol Invest. 2001 Mar;24(3):199-203. To Reference
Ref 2Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab. 2001 Mar;15(1):79-94. To Reference
Ref 3J Med Chem. 2006 Jan 26;49(2):748-59.Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. To Reference
Ref 419-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29. To Reference
Ref 5J Med Chem. 1990 Sep;33(9):2452-5.Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. To Reference
Ref 6Bioorg Med Chem Lett. 1999 Jun 7;9(11):1553-8.Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives. To Reference



 

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