Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01185

Target Information
NameAldehyde dehydrogenase, mitochondrial    
Type of targetResearch target    
SynonymsALDH class 2    
ALDH-E2    
ALDH2    
ALDHI    
Aldehyde dehydrogenase    
Human liver mitochondrial aldehyde dehydrogenase    
Mitochondrial aldehyde dehydrogenase    
DiseaseAlcoholism
[ICD9: 303   ICD10: F10.2]
[1][2]
BioChemical ClassOxidoreductases acting on the aldehyde or oxo group of donors    
EC NumberEC 1.2.1.3
Pathway3-Chloroacrylic acid degradation
Arginine and proline metabolism
Ascorbate and aldarate metabolism
Butanoate metabolism
Fatty acid metabolism
Glycerolipid metabolism
Glycolysis / Gluconeogenesis
Histidine metabolism
Limonene and pinene degradation
Lysine degradation
Metabolic pathways
Propanoate metabolism
Pyruvate metabolism
Tryptophan metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
UniProt IDP05091
PDB Structure1CW3; 1NZW; 1NZX; 1NZZ; 1O00; 1O01; 1O02; 1O04; 1O05; 1ZUM; 2ONM; 2ONN; 2ONO; 2ONP; 2VLE; 3INJ; 3INL; 3N80; 3N81; 3N82; 3N83; 3SZ9; 4FQF; 4FR8.    
SequenceMLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
Target ValidationClick to Find Target Validation Information.    
InhibitorCrotonaldehyde[3]
Daidzin[3]
ISOFORMONENTIN[4]
Nicotinamide-Adenine-Dinucleotide[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram. Chem Biol Interact. 2003 Feb 1;143-144:149-58. To Reference
Ref 2Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram. Biochem Pharmacol. 1998 Apr 1;55(7):1099-103. To Reference
Ref 3Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 4J Med Chem. 2008 Aug 14;51(15):4482-7. Epub 2008 Jul 10.Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. To Reference



 

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