Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDR01197

Target Information
NameThyrotropin-releasing hormone receptor    
Type of targetResearch target    
Thyroliberin receptor    
DiseaseAlcohol dependence
[ICD9: 303   ICD10: F10.2]
Anxiety disorder, unspecified
[ICD9: 300   ICD10: F40-F42]
BioChemical ClassG-protein coupled receptor (rhodopsin family)    
PathwayCalcium signaling pathway
Neuroactive ligand-receptor interaction
UniProt IDP34981
FunctionReceptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.    
Target ValidationClick to Find Target Validation Information.    
QSAR ModelClick to Find Target QSAR Model.    
InhibitorCORYMBONE B[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1The psychiatric management of patients with alcohol dependence. Curr Treat Options Neurol. 2007 Sep;9(5):381-92. To Reference
Ref 2Antidepressants alleviate the impact of reinforcer downshift. Eur Neuropsychopharmacol. 2009 Jan;19(1):41-8. Epub 2008 Sep 20. To Reference
Ref 3J Nat Prod. 2008 May;71(5):881-3. Epub 2008 Apr 16.Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata. To Reference
Ref 4J Nat Prod. 2008 May;71(5):884-6. Epub 2008 Apr 12.Spongian diterpenes with thyrotropin releasing hormone receptor 2 binding affinity from Spongia sp. To Reference


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