Therapeutic Targets Database
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TTD Target ID: TTDR01224

Target Information
NameCarbonic anhydrase I    
Type of targetResearch target    
SynonymsCA-I    
Carbonate dehydratase I    
Carbonic anhydrase B    
DiseaseGlaucoma
[ICD9: 365   ICD10: H40-H42]
[1]
Hypertension
[ICD9: 401   ICD10: I10, I11, I12, I13, I15]
[2]
Pancreatic cancer
[ICD9: 157   ICD10: C25]
[3]
BioChemical ClassCarbon-oxygen lyases    
EC NumberEC 4.2.1.1
PathwayNitrogen metabolism
UniProt IDP00915
PDB Structure1AZM; 1BZM; 1CRM; 1CZM; 1HCB; 1HUG; 1HUH; 1J9W; 1JV0; 2CAB; 2FOY; 2FW4; 2IT4; 2NMX; 2NN1; 2NN7; 3LXE; 3W6H; 3W6I.    
FunctionReversible hydration of carbon dioxide.    
SequenceMASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV PMQHNNRPTQPLKGRTVRASF
Target ValidationClick to Find Target Validation Information.    
QSAR ModelClick to Find Target QSAR Model.    
Inhibitor2,4-dichloro-5-sulfamoylbenzoic acid[4]
2- (biphenyl-4-yl)vinylboronic acid[5]
2-Hydroxycinnamic acid[6]
2-oxo-2H-thiochromene-3-carboxylic acid[7]
3-phenylprop-1-enylboronic acid[5]
4-azidobenzenesulfonamide[8]
4-bromophenylboronic acid[5]
4-butylphenylboronic acid[5]
4-ethynyl benzene sulfonamide[9]
4-methoxyphenylboronic acid[5]
4-methylstyrylboronic acid[5]
4-nitrophenyl phosphate[10]
4-phenoxyphenylboronic acid[5]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid[7]
Aminobenzolamide derivative[11]
Azide[12]
BENZENESULFONAMIDE[13]
BENZOLAMIDE[14]
CATECHIN[6]
CHLORIDE[15]
COUMARIN[16]
COUMATE[17]
CURCUMIN[6]
CYANATE[12]
Cynooxide anion[18]
Ditiocarb sodium[19]
ELLAGIC ACID[20]
EMATE[21]
FERULIC ACID[20]
GALLICACID[20]
HERNIARIN[7]
HYDROSULFIDE[12]
INDISULAM[22]
IODIDE[15]
Indan-5-sulfonic acid amide[23]
N- (prop-2-ynyl)-4-sulfamoylbenzamide[24]
N-hydroxysulfamide[25]
N-hydroxysulfonamides[26]
N-unsubstituted carbamate esters[27]
NITRATE[15]
NSC-654077[28]
PARABEN[20]
PARAOXON[10]
PHENOL[6]
PHENYLDIFLUOROMETHANESULFONAMIDE[21]
PHENYLMETHANESULFONAMIDE[21]
PHENYLSULFAMATE[21]
Phenyl Boronic acid[15]
SACCHARIN[29]
SALICYLATE[30]
SULFAMATE[15]
SULFAMIDE[15]
SULFATE[15]
Sulfenamido-sulfonamides[31]
Syringic Acid[20]
Thioureido sulfonamide[32]
Thioureido sulfonamide[32]
Thioureido sulfonamide[32]
[Au (CN)2]-[33]
[Cu (CN)2]-[33]
beta-naphthylboronic acid[5]
biphenylboronic acid[5]
decyl sulfamate[34]
hexane-1,6-diamine[35]
octyl sulfamate[34]
p-Coumaric Acid[20]
pentane-1,5-diamine[35]
phenethylboronic acid[5]
phenoxyarsonous acid[15]
prop-2-ynyl 4-sulfamoylbenzoate[24]
sodium trithiocarbonate[19]
styrylboronic acid[5]
sulfanilamide derivative [36]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties. J Enzyme Inhib. 2001;16(2):113-23. To Reference
Ref 2Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I. Cardiovasc Drugs Ther. 2000 Oct;14(5):523-8. To Reference
Ref 3Immunohistochemical demonstration of the carbonic anhydrase isoenzymes I and II in pancreatic tumours. Histochem J. 1995 Feb;27(2):133-8. To Reference
Ref 4Bioorg Med Chem. 2010 Jan 15;18(2):930-8. Epub 2009 Nov 20.Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex. To Reference
Ref 5Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. To Reference
Ref 6Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. To Reference
Ref 7J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. To Reference
Ref 8Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. Epub 2008 Jul 10.Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. To Reference
Ref 9J Med Chem. 2008 Mar 27;51(6):1945-53. Epub 2008 Feb 29.Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. To Reference
Ref 10Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. To Reference
Ref 11Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. To Reference
Ref 12Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. To Reference
Ref 13Nat Chem Biol. 2009 May;5(5):341-3. Epub 2009 Mar 29.Ligand-directed tosyl chemistry for protein labeling in vivo. To Reference
Ref 14Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30.Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. To Reference
Ref 15Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. To Reference
Ref 16Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. To Reference
Ref 17Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. Epub 2008 Jul 5.Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. To Reference
Ref 18Bioorg Med Chem Lett. 2004 Sep 6;14(17):4563-7.Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. To Reference
Ref 19Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7. Epub 2009 Feb 26.Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. To Reference
Ref 20Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. To Reference
Ref 21Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. To Reference
Ref 22Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. To Reference
Ref 23Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. To Reference
Ref 24J Med Chem. 2006 Nov 2;49(22):6539-48.A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". To Reference
Ref 25Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV. To Reference
Ref 26Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84. To Reference
Ref 27Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50. To Reference
Ref 28J Med Chem. 2008 Jun 12;51(11):3051-6. Epub 2008 Mar 19.Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. To Reference
Ref 29Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. To Reference
Ref 30Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. To Reference
Ref 31Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90. To Reference
Ref 32Bioorg Med Chem Lett. 2005 Sep 1;15(17):3821-7.Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. To Reference
Ref 33Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13.Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. To Reference
Ref 34J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. To Reference
Ref 35J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. To Reference
Ref 36Bioorg Med Chem Lett. 2005 Jun 15;15(12):3096-101.Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. To Reference



 

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National University of Singapore, Singapore


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