Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01232

Target Information
NameGlutathione reductase, mitochondrial    
Type of targetResearch target    
SynonymsGR    
GRase    
Glutathione reductase    
DiseaseMalaria
[ICD9: 084   ICD10: B50-B54]
[1][2][3]
Parasitic diseases[4]
BioChemical ClassOxidoreductases acting on a sulfur group of donors    
EC NumberEC 1.8.1.7
PathwayGlutathione metabolism
UniProt IDO15770
P00390
PDB Structure1ALG; 1BWC; 1DNC; 1GRA; 1GRB; 1GRE; 1GRF; 1GRG; 1GRH; 1GRT; 1GSN; 1K4Q; 1XAN; 2AAQ; 2GH5; 2GRT; 3DJG; 3DJJ; 3DK4; 3DK8; 3DK9; 3GRS; 3GRT; 3SQP; 4GR1; 4GRT; 5GRT.    
FunctionMaintain high levels of reduced glutathione in the cytosol.    
SequenceMALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
Target ValidationClick to Find Target Validation Information.    
Inhibitor1- (2'-chlorophenyl)penta-1,4-dien-3-one[5]
2,4,6 trinitrobenzene sulfonate 1,3-bis (2-chlorethyl)-1-nitrosourea[4]
3,6-Dihydroxy-Xanthene-9-Propionic Acid[6]
3,7-Bis-dimethylamino-phenothiazin-5-ylium[7]
3- (Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol[6]
3-Sulfinoalanine[6]
4-nitrobenzo[c][1,2,5]thiadiazole[8]
Flavin-Adenine Dinucleotide[6]
Glutathionylspermidine Disulfide[6]
Meta-Nitro-Tyrosine[6]
Methylene blue[2]
Nicotinamide-Adenine-Dinucleotide[6]
Oxidized Glutathione Disulfide[9]
Oxidized glutathione[4]
trans- (1S[10]
trans- (R[10]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development. J Mol Biol. 2003 May 9;328(4):893-907. To Reference
Ref 2Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett. 1998 Feb 6;422(3):311-4. To Reference
Ref 3Thiol-based redox metabolism of protozoan parasites. Trends Parasitol. 2003 Jul;19(7):320-8. To Reference
Ref 4The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401. To Reference
Ref 5J Med Chem. 2005 Nov 17;48(23):7400-10.Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. To Reference
Ref 6Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 7J Med Chem. 2004 Nov 18;47(24):5972-83.5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials. To Reference
Ref 8Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. Epub 2006 Feb 3.Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. To Reference
Ref 9Nucleic Acids Res. 2011 January; 39(Database issue): D1035¨CD1041. DrugBank 3.0: a comprehensive resource for ¡®Omics¡¯ research on drugs To Reference
Ref 10Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3. Epub 2009 Apr 24.In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. To Reference



 

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