Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01337

Target Information
NameHistone Deacetylase 8    
Type of targetResearch target    
DiseaseNot Available
Target ValidationClick to Find Target Validation Information.    
QSAR ModelClick to Find Target QSAR Model.    
Inhibitor (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one[1]
2- (methylsulfonylthio)ethyl 2-propylpentanoate[2]
4-Benzoylamino-N-hydroxy-benzamide[3]
4-Butyrylamino-N-hydroxy-benzamide[4]
4-Chloro-N- (5-hydroxycarbamoyl-pentyl)-benzamide[5]
4-Dimethylamino-N- (6-mercapto-hexyl)-benzamide[6]
4-Hydroxy-N- (5-hydroxycarbamoyl-pentyl)-benzamide[5]
4-Phenylbutyrohydroxamic acid[7]
5- (4-Chloro-phenyl)-pentanoic acid hydroxyamide[8]
5- (4-hydroxyphenyl)-3H-1,2-dithiole-3-thione[2]
5-Mercapto-pentanoic acid phenylamide[6]
6- (2-Bromo-acetylamino)-hexanoic acid phenylamide[6]
6- (2-mercaptoacetamido)-N-phenylhexanamide[9]
6-Mercapto-hexanoic acid phenylamide[6]
6-Phenoxy-hexane-1-thiol[6]
6-benzenesulfinylhexanoic acid hydroxamide[10]
6-benzenesulfonylhexanoic acid hydroxamide[10]
6-phenylsulfanylhexanoic acid hydroxamide[10]
7- (Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one[1]
7- (Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one[11]
7- (Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one[1]
7- (Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one[1]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide[6]
7-Mercapto-heptanoic acid biphenyl-3-ylamide[6]
7-Mercapto-heptanoic acid biphenyl-4-ylamide[6]
7-Mercapto-heptanoic acid phenylamide[6]
7-Mercapto-heptanoic acid pyridin-3-ylamide[6]
7-Mercapto-heptanoic acid quinolin-3-ylamide[6]
8- (Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one[1]
8-Mercapto-octanoic acid phenylamide[6]
8-Oxo-8-phenyl-octanoic acid[5]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide[11]
9- (Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one[11]
9-mercapto-8-oxo-N-phenylnonanamide[9]
Azithromycin-N-benzyltriazolylhexahydroxamic Acid[12]
Azithromycin-N-benzyltriazolylnonahydroxamic Acid[12]
Azithromycin-N-benzyltriazolyloctahydroxamic Acid[12]
Azithromycinarylalkylhydroxamic Acid[12]
Cyclostellettamine derivative[13]
Desclasinose Azithromycinarylalkyl Hydroxamate[12]
N- (2-Mercapto-ethyl)-N'-phenyl-oxalamide[14]
N- (2-Mercapto-ethyl)-N'-phenyl-succinamide[14]
N- (5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide[5]
N- (6-Hydroxycarbamoyl-hexyl)-benzamide[5]
N- (6-Mercapto-hexyl)-benzamide[6]
N-Hydroxy-4- ([3]
N-Hydroxy-4- ([3]
N-Hydroxy-4- (2-phenyl-butyrylamino)-benzamide[3]
N-Hydroxy-4- (3-phenyl-propionylamino)-benzamide[3]
N-Hydroxy-4- (4-phenyl-butyrylamino)-benzamide[3]
N-Hydroxy-4- (5-phenyl-pentanoylamino)-benzamide[3]
N-Hydroxy-4- (pentanoylamino-methyl)-benzamide[4]
N-Hydroxy-4- (phenylacetylamino-methyl)-benzamide[4]
N-Hydroxy-4-phenylacetylamino-benzamide[3]
N-hydroxy-1-naphthamide[15]
N-hydroxy-3- (naphthalen-1-yl)acrylamide[15]
N-hydroxy-3-phenoxybenzamide[15]
N-hydroxy-4- (naphthalen-1-yl)benzamide[15]
NILTUBACIN[7]
Octanedioic acid hydroxyamide pyridin-2-ylamide[5]
Octanedioic acid hydroxyamide pyridin-4-ylamide[5]
PSAMMAPLIN A[11]
S-2,9-dioxo-9- (phenylamino)nonyl ethanethioate[9]
ST-2986[16]
ST-2987[16]
ST-3050[16]
Suberohydroxamic acid[7]
Thioacetic acid S- (6-phenylcarbamoyl-hexyl) ester[6]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13.Heterocyclic ketones as inhibitors of histone deacetylase. To Reference
Ref 2Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. Epub 2008 Feb 8.New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. To Reference
Ref 3J Med Chem. 2005 Aug 25;48(17):5530-5.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. To Reference
Ref 4J Med Chem. 2004 Jan 15;47(2):467-74.Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. To Reference
Ref 5J Med Chem. 2002 Feb 14;45(4):753-7.Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. To Reference
Ref 6J Med Chem. 2005 Feb 24;48(4):1019-32.Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. To Reference
Ref 7Nat Chem Biol. 2010 Mar;6(3):238-243. Epub 2010 Feb 7.Chemical phylogenetics of histone deacetylases. To Reference
Ref 8Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. To Reference
Ref 9J Med Chem. 2008 Mar 27;51(6):1505-29. Epub 2008 Feb 5.Histone deacetylase inhibitors: from bench to clinic. To Reference
Ref 10J Med Chem. 2006 Jan 26;49(2):800-5.Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. To Reference
Ref 11J Med Chem. 2003 Nov 20;46(24):5097-116.Histone deacetylase inhibitors. To Reference
Ref 12J Med Chem. 2009 Jan 22;52(2):456-68.Non-peptide macrocyclic histone deacetylase inhibitors. To Reference
Ref 13Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. To Reference
Ref 14Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. To Reference
Ref 15Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. To Reference
Ref 16Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. Epub 2009 Feb 12.N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. To Reference



 

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