Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDR01345

Target Information
NamemRNA of PDK-1 (also known as PDPK-1, 3-phosphoinositide-dependent protein kinase-1, PtdIns(3,4,5)P3-dependent kinase-1, PKB kinase)    
Type of targetResearch target    
DiseaseNot Available
UniProt IDO15530
PDB Structure1H1W; 1OKY; 1OKZ; 1UU3; 1UU7; 1UU8; 1UU9; 1UVR; 1W1D; 1W1G; 1W1H; 1Z5M; 2BIY; 2PE0; 2PE1; 2PE2; 2R7B; 2VKI; 2XCH; 2XCK; 3H9O; 3HRC; 3HRF; 3ION; 3IOP; 3NAX; 3NAY; 3NUN; 3NUS; 3NUU; 3NUY; 3ORX; 3ORZ; 3OTU; 3PWY; 3QC4; 3QCQ; 3QCS; 3QCX; 3QCY; 3QD0; 3QD3; 3QD4; 3RCJ; 3RWP; 3RWQ; 3SC1; 4A06; 4A07; 4AW0; 4AW1.    
Target ValidationClick to Find Target Validation Information.    
Inhibitor (Z)-3-[1]
BX-201[1]
BX-517[1]
NU-6102[2]
SU-6689[1]
AntisenseISIS 29219[3]
ISIS 29223[3]
ISIS 29224[3]
ISIS 29232[3]
ISIS 29233[3]
ISIS 29234[3]
ISIS 29236[3]
ISIS 29237[3]
ISIS 29239[3]
ISIS 29243[3]
ISIS 29244[3]
ISIS 29246[3]
ISIS 29255[3]
ISIS 29256[3]
ISIS 29257[3]
ISIS 29469[3]
ISIS 29470[3]
ISIS 29471[3]
ISIS 29475[3]
ISIS 29477[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. To Reference
Ref 2Bioorg Med Chem Lett. 2006 Mar 1;16(5):1353-7. Epub 2005 Dec 1.Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. To Reference
Ref 3US Patent 6124272 To Reference



 

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