Therapeutic Targets Database
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TTD Target ID: TTDR01369

Target Information
NamemRNA of human 5-lipoxygenase    
Type of targetResearch target    
DiseaseNot Available
UniProt IDP09917
PDB Structure2ABV; 3O8Y; 3V92; 3V98; 3V99.    
Target ValidationClick to Find Target Validation Information.    
Inhibitor (+)-3,3'-bisdemethyltanegool[1]
(-)-3,3'-bisdemethylpinoresinol[1]
(-)-pinoresinol[1]
(-)-zileuton[2]
(N-[3]
1- (4-methoxyphenyl)-3-[4]
1- (4-methoxyphenyl)-3-[4]
1- (4-methoxyphenyl)-3-[4]
2,4'-Diacetoxy-5,3'-di- (2-propenyl)-biphenyl[5]
2,4'-Dimethoxy-5,3'-di- (2-propenyl)-biphenyl[5]
2,4,5-Triarylimidazole analogue[6]
2- (4-methoxyphenyl)-N-[4]
2- (benzyloxy)naphthalene[7]
2-phenyl-N- (1,3,4-thiadiazol-2-yl)acetamide[4]
2-phenyl-N- (thiazol-2-yl)acetamide[4]
3,4,5-trimethoxy-N- (thiazol-2-yl)benzamide[4]
3-methoxy-N- (1,3,4-thiadiazol-2-yl)benzamide[4]
3-methoxy-N- (4-methylthiazol-2-yl)benzamide[4]
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol[5]
4- (dimethylamino)-N-[4]
4-methoxy-N- (thiazol-2-yl)benzamide[4]
5,3'-Dipropyl-biphenyl-2,4'-diol[5]
CMI-977[8]
HONOKIOL[5]
ISAINDIGOTONE[9]
JASPAQUINOL[2]
KAEMPFEROL[1]
L-689065[10]
L-702-539[11]
L-746530[12]
METHYLHONOKIOL[5]
Methyl 2- (Benzylamino)-1H-indole-3-carboxylate[3]
Methyl 2- (Diallylamino)-1H-indole-3-carboxylate[3]
N- (1,3,4-thiadiazol-2-yl)benzamide[4]
N- (3-phenoxycinnamyl)-N-hydroxyacetamide[13]
N- (4-methylthiazol-2-yl)-2-phenylacetamide[4]
N- (4-methylthiazol-2-yl)benzamide[4]
N- (5-methylthiazol-2-yl)-2-phenylacetamide[4]
N- (5-methylthiazol-2-yl)benzamide[4]
N- (thiazol-2-yl)benzamide[4]
N-hydroxy-N-[1- (4-isobutylphenyl)ethyl]urea[14]
N-hydroxycarbamate derivative[15]
N-hydroxycarbamate derivative[15]
N-hydroxycarbamate derivative[15]
N-hydroxycarbamate derivative[15]
N-hydroxycarbamate derivative[15]
N-hydroxycarbamate derivative[15]
PD-169316[6]
PUUPEHEDIONE[2]
PUUPEHENONE[2]
SB-202190[6]
SB-203580[6]
TEBUFELONE[16]
ZD-2138[17]
isojaspic acid[2]
jaspic acid[2]
AntisenseISIS 1820[18]
ISIS 1821[18]
ISIS 1822[18]
ISIS 1827[18]
ISIS 1831[18]
ISIS 2177[18]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1J Nat Prod. 2007 May;70(5):859-62. Epub 2007 Mar 23.Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. To Reference
Ref 2J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. To Reference
Ref 3J Med Chem. 2009 Jun 11;52(11):3474-83.Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. To Reference
Ref 4J Med Chem. 2007 May 31;50(11):2640-6. Epub 2007 Apr 27.Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. To Reference
Ref 5Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. Epub 2009 May 18.Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. To Reference
Ref 6Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995) To Reference
Ref 7Nat Chem Biol. 2009 Aug;5(8):585-92. Epub 2009 Jun 28.Bioactivity-guided mapping and navigation of chemical space. To Reference
Ref 8J Med Chem. 2005 Oct 20;48(21):6523-43.Designed multiple ligands. An emerging drug discovery paradigm. To Reference
Ref 9J Nat Prod. 2001 Oct;64(10):1297-300.Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. To Reference
Ref 10J Med Chem. 1993 Sep 17;36(19):2771-87.Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. To Reference
Ref 11J Med Chem. 1997 Aug 29;40(18):2866-75.Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. To Reference
Ref 12Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. Epub 2006 Feb 7.Substituted coumarins as potent 5-lipoxygenase inhibitors. To Reference
Ref 13J Med Chem. 2008 Sep 11;51(17):5449-53. Epub 2008 Aug 19.Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. To Reference
Ref 14J Med Chem. 1997 Feb 28;40(5):819-24.Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. To Reference
Ref 15Bioorg Med Chem Lett. 2005 Feb 15;15(4):1083-5.5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds. To Reference
Ref 16J Med Chem. 1998 Aug 27;41(18):3515-29.New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position. To Reference
Ref 17Bioorg Med Chem. 2010 Jun 1;18(11):3910-24. Epub 2010 Apr 18.Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. To Reference
Ref 18US Patent 5530114 To Reference



 

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