Therapeutic Targets Database
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TTD Target ID: TTDR01395

Target Information
NamemRNA of kinesin-like 1    
Type of targetResearch target    
DiseaseNot Available
UniProt IDP52732
PDB Structure1II6; 1Q0B; 1X88; 1YRS; 2FKY; 2FL2; 2FL6; 2FME; 2G1Q; 2GM1; 2IEH; 2PG2; 2Q2Y; 2Q2Z; 2UYI; 2UYM; 2WOG; 2X2R; 2X7C; 2X7D; 2X7E; 2XAE; 3CJO; 3HQD; 3K3B; 3K5E; 3KEN; 3L9H; 3ZCW; 4A1Z; 4A28; 4A50; 4A51; 4A5Y; 4AP0; 4AQV; 4AQW; 4AS7; 4BBG.    
Target ValidationClick to Find Target Validation Information.    
Inhibitor (S)-dimethylenastron[1]
(S)-enastron[1]
1- (7-methyl-9H-carbazol-3-yl)ethanone[2]
1- (trifluoromethyl)-9H-carbazole[2]
1-tert-butyl-9H-carbazole[2]
11H-benzo[a]carbazole[2]
2,3,4,11-tetrahydro-1H-benzo[a]carbazole[2]
2- (difluoromethyl)-9H-carbazole[2]
2- (trifluoromethoxy)-9H-carbazole[2]
2- (trifluoromethyl)-9H-carbazole[2]
2-ethyl-9H-carbazole[2]
2-isopropyl-9H-carbazole[2]
2-methyl-6- (trifluoromethyl)-9H-carbazole[2]
2-methyl-9H-carbazole[2]
2-tert-butoxy-9H-carbazole[2]
2-tert-butyl-7- (trifluoromethyl)-9H-carbazole[2]
2-tert-butyl-9H-carbazole[2]
3- (trifluoromethyl)-9H-carbazole[2]
3-methyl-6- (trifluoromethyl)-9H-carbazole[2]
3-tert-butyl-9H-carbazole[2]
4'- (trifluoromethyl)-4-biphenylol[3]
4'- (trifluoromethyl)-4-biphenylsulfonamide[3]
4'- (trifluoromethyl)-4-biphenylyl carbamate[3]
4'- (trifluoromethyl)-4-biphenylyl sulfamate[3]
4'-trifluoromethyl-biphenyl-4-ylamine[3]
4- (trifluoromethyl)biphenyl[3]
6-fluoro-2-methyl-9H-carbazole[2]
7-tert-butyl-9H-carbazole-3-carboxylic acid[2]
9-methyl-2- (trifluoromethyl)-9H-carbazole[2]
9H-carbazole-2-carbaldehyde[2]
9H-carbazole-3-carbaldehyde[2]
EMD-534085[4]
N- (4'-bromo-3,3'-difluoro-4-biphenylyl)urea[3]
N- (4'-chloro-4-biphenylyl)methanesulfonamide[3]
N- (4'-isopropyl-4-biphenylyl)urea[3]
N- (4'-methyl-4-biphenylyl)urea[3]
N- (4'-t-butyl-4-biphenylyl)urea[3]
N-[3'- (trifluoromethyl)-4-biphenylyl]urea[3]
N-[4'- (ethylsulfonyl)-3-fluoro-4-biphenylyl]urea[3]
N-[4'- (trifluoromethyl)-4-biphenylyl]sulfamide[3]
N-[4'- (trifluoromethyl)-4-biphenylyl]thiourea[3]
N-[4'- (trifluoromethyl)-4-biphenylyl]urea[3]
N-[4- (1,3-benzodioxol-5-yl)phenyl]sulfamide[3]
N-{4'-[ (trifluoromethyl)sulfonyl]-4-biphenyl}urea[3]
N-{4'-[ (trifluoromethyl)thio]-4-biphenyl}urea[3]
SB-731489[3]
adociasulfate-2[5]
methyl 7-tert-butyl-9H-carbazole-3-carboxylate[2]
methyl 9H-carbazole-2-carboxylate[2]
methyl[4'- (trifluoromethyl)-4-biphenylyl]amine[3]
AntisenseISIS 183881[6]
ISIS 183881[7]
ISIS 183882[7]
ISIS 183883[7]
ISIS 183897[7]
ISIS 183901[7]
ISIS 183910[7]
ISIS 183911[7]
ISIS 183912[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1J Med Chem. 2010 Aug 12;53(15):5676-83.Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. To Reference
Ref 2J Med Chem. 2010 Jul 8;53(13):5054-8.Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. To Reference
Ref 3J Med Chem. 2007 Oct 4;50(20):4939-52. Epub 2007 Aug 29.Novel ATP-competitive kinesin spindle protein inhibitors. To Reference
Ref 4Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5. Epub 2010 Jan 25.The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. To Reference
Ref 5J Med Chem. 2006 Aug 10;49(16):4857-60.Inhibition of kinesin motor proteins by adociasulfate-2. To Reference
Ref 6US Patent 7407943 To Reference
Ref 7US Patent 7163927 To Reference



 

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