Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDS00018

Target Information
NameGamma-aminobutyric acid receptor    
Type of targetSuccessful target    
SynonymsGABA receptor    
DiseaseAnxiety disorder, unspecified
[ICD9: 300   ICD10: F40-F42]
Helminth infection
[ICD9: 001-139   ICD10: A00-B99]
Huntington's disease
[ICD9: 294.1, 333.4   ICD10: F02.2, G10]
Hypertonia and apnoeic episodes[4]
Mood [affective] disorders[5]
Parkinson's disease
[ICD9: 332   ICD10: F02.3, G20]
PiperazineApprovedAscariasis and enterobiasis[2]
Phentermine+topiramatePhase IIIObesity[10]
BL-1020Phase II completedSchizophrenia[11]
GanaxolonePhase II completedEpilepsy[12][13][14]
DextofisopamPhase IIIrritable bowel syndrome[15]
PhenylbutyratePhase IIUrea cycle disorders[16]
RG1662Phase ICognitive disorders in patients with Down's syndrome
E-2007Terminated in Phase IIIParkinsoní»s disease[17][18]
BioChemical ClassChloride channel    
PathwayNeuroactive ligand-receptor interaction
Target ValidationClick to Find Target Validation Information.    
Inhibitor (4R)-4-ammoniopentanoate[19]
Piperidine-4-carboxylic acid[45]
Pyrrolidin-3-yl-acetic acid[39]
Ro-15-3505,   Sarmazenil[51]
Toluene-1-diazonium-3-sulfonic acid anion[57]
ridine-5-carboxylic acid ethyl ester[61]
ModulatorGabapentin GR[63]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
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