Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00026

Target Information
NameAlpha adrenergic receptor    
Type of targetSuccessful target    
SynonymsAlpha-adrenoceptor    
DiseaseDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
[1]
Hypertonicity of bladder
[ICD9: 188   ICD10: C67]
[2]
Drug(s)BevantololApprovedHypertension[3][4]
DapiprazoleApprovedMydriasis[5]
DihydroergotamineApprovedMigraine headaches[6]
DroperidolApprovedNausea and vomiting[7]
EphedrineApprovedAsthma and bronchitis[8]
ErgonovineApprovedPostpartum haemorrhage[9]
Guanadrel SulfateApprovedHypertension[10]
MephentermineApprovedHypotension[11]
MetaraminolApprovedHypotension[12]
MethyldopaApprovedHypertension[13]
NaphazolineApprovedMinor eye irritations[14]
PhenoxybenzamineApprovedHypertension[15]
PhentolamineApprovedDermal necrosis[16]
PhenylephrineApprovedOphthalmic disorders[17][1]
PseudoephedrineApprovedNasal congestion[18][19]
ThioridazineApprovedSchizophrenia[20][21]
TolazolineApprovedPeripheral vasoconstriction[22]
BioChemical ClassG-protein coupled receptor (rhodopsin family)    
PathwayCalcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Related US Patent6,486,190
Target ValidationClick to Find Target Validation Information.    
AgonistDihydroergotamine[6]
Ephedrine[8]
Ergonovine[9]
Mephentermine[11]
Metaraminol[12]
Methyldopa[13]
Naphazoline[14]
Phenylephrine[17][1]
AntagonistBevantolol[3][4]
Dapiprazole[5]
Guanadrel Sulfate[10]
Phenoxybenzamine[15]
Phentolamine[16]
Thioridazine[20][21]
Tolazoline[22]
StimulatorPseudoephedrine[18][19]
BinderDroperidol[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Intracellular Ca2+ and adrenergic responsiveness of cardiac myocytes in streptozotocin-induced diabetes. Clin Exp Pharmacol Physiol. 1999 Apr;26(4):347-53. To Reference
Ref 2Potential therapeutic targets for treatment of the overactive bladder. World J Urol. 2001 Nov;19(5):307-11. To Reference
Ref 3Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique. Arch Pharm Res. 2007 Jul;30(7):890-7. To Reference
Ref 4Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. To Reference
Ref 5Effect of ibopamine on aqueous humor production in normotensive humans. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4853-8. To Reference
Ref 6Current and prospective pharmacological targets in relation to antimigraine action. Naunyn Schmiedebergs Arch Pharmacol. 2008 Oct;378(4):371-94. Epub 2008 Jul 15. To Reference
Ref 7Alpha-adrenergic blockade: a possible mechanism of tocolytic action of certain benzodiazepines in a postpartum rat model in vivo. Life Sci. 2003 Jan 24;72(10):1093-102. To Reference
Ref 8The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol. 2006 Dec;19(4):204-7. To Reference
Ref 9Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors. J Pharm Pharmacol. 1988 Feb;40(2):137-9. To Reference
Ref 10Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate. Clin Pharmacol Ther. 1990 Nov;48(5):537-43. To Reference
Ref 11Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. To Reference
Ref 12Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Int J Cancer. 1998 Jul 29;77(3):467-9. To Reference
Ref 13Centrally acting antihypertensive agents: an update. J Clin Hypertens (Greenwich). 2007 May;9(5):399-405. To Reference
Ref 14Decongestants in treatment of nasal obstruction. Otolaryngol Pol. 1999;53(3):347-52. To Reference
Ref 15Catecholamine-secreting neuroblastoma in a 4-month-old infant: perioperative management. J Clin Anesth. 2009 Feb;21(1):54-6. To Reference
Ref 16Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R330-6. Epub 2009 May 27. To Reference
Ref 17MMP-2 Induced Vein Relaxation via Inhibition of [Ca(2+)](e)-Dependent Mechanisms of Venous Smooth Muscle Contraction. Role of RGD Peptides. J Surg Res. 2008 Oct 24. [Epub ahead of print] To Reference
Ref 18Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2. To Reference
Ref 19Drugs for cough and cold symptoms in hypertensive patients. Am Fam Physician. 1985 Mar;31(3):183-7. To Reference
Ref 20Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. To Reference
Ref 21Models of drug treatment in the attention deficit disorder with hyperactivity. Rev Neurol. 2002 Feb;34 Suppl 1:S98-S106. To Reference
Ref 22Comparative effects of tolazoline and nitroprusside on human isolated radial artery. Ann Thorac Surg. 2006 Jan;81(1):125-31. To Reference



 

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