Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00027

Target Information
NameAlpha-1 adrenergic receptor    
Type of targetSuccessful target    
SynonymsAlpha1-adrenoceptor    
DiseaseBenign prostate hyperplasia
[ICD9: 600   ICD10: N40]
[1][2]
Chronic cardiac failure
[ICD9: 428.0   ICD10: I50]
[3]
Erectile dysfunction
[ICD9: 302.72, 607.84   ICD10: F52.2, N48.4]
[4]
Gastrointestinal disturbances[5]
Hyperlipidemia
[ICD9: 272.0-272.4   ICD10: E78]
[6]
Hypertension
[ICD9: 401   ICD10: I10, I11, I12, I13, I15]
[7][8]
Lower urinary tract symptoms associated with benign prostatic hyperplasia
[ICD9: 600   ICD10: N40]
[9]
Nasal congestion
[ICD9: 478.19   ICD10: J34.89]
[6]
Orthostatic hypotension
[ICD9: 458.0   ICD10: I95.1]
[10]
Prostate cancer
[ICD9: 185   ICD10: C61]
[1]
Shy-Drager syndrome[11]
Drug(s)CarvedilolApprovedCongestive Heart Failure[12]
ErgotamineApprovedHeadache[13]
LabetalolApprovedHypertension[12]
MidodrineApprovedSymptomatic orthostatic hypotension[10]
PhenylpropanolamineApprovedObesity[14]
PrazosinApprovedHypertension[15][5]
TamsulosinApprovedBenign prostatic hyperplasia[16][9]
BioChemical ClassG-protein coupled receptor (rhodopsin family)    
PathwayCalcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Related US Patent6,291,498
6,410,565
6,410,735
6,420,559
Target ValidationClick to Find Target Validation Information.    
QSAR ModelClick to Find Target QSAR Model.    
AgonistErgotamine[13]
Midodrine[10]
Phenylpropanolamine[14]
AntagonistCarvedilol[12]
DC-015[6]
Labetalol[12]
Metazosin[3]
Prazosin[15][5]
Tamsulosin[16][9]
Urapidil[8]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component. Prostate Cancer Prostatic Dis. 2002;5(2):88-95. To Reference
Ref 2alpha-Adrenoceptor antagonists in the treatment of benign prostate hyperplasia. Pharmacology. 2002 Jul;65(3):119-28. To Reference
Ref 3Metazosin tablets (Kenosin) in the treatment of chronic congestive heart failure. Cas Lek Cesk. 1995 Sep 20;134(18):590-3. To Reference
Ref 4Recovery of erectile function after brief aggressive antihypertensive therapy. J Urol. 2002 Jul;168(1):348-54. To Reference
Ref 5Characterization of alpha-adrenoceptor subtypes in smooth muscle of equine ileum. Am J Vet Res. 2001 Sep;62(9):1370-4. To Reference
Ref 6Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats. J Biomed Sci. 1996 Apr;3(2):108-116. To Reference
Ref 7Doxazosin, an alpha1-adrenoceptor antagonist, inhibits serotonin-induced shape change in human platelets. J Hum Hypertens. 2001 Mar;15(3):203-7. To Reference
Ref 8Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55. To Reference
Ref 9Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs Aging. 2002;19(2):135-61. To Reference
Ref 10Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505. To Reference
Ref 11Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy. Nat Med. 2000 Dec;6(12):1388-94. To Reference
Ref 12Beta-blockers in the treatment of hypertension: are there clinically relevant differences? Postgrad Med. 2009 May;121(3):90-8. To Reference
Ref 13Reversal of ergotamine-induced vasospasm following methylprednisolone. Clin Toxicol (Phila). 2008 Dec;46(10):1074-6. To Reference
Ref 14Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35. To Reference
Ref 15Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Auton Autacoid Pharmacol. 2009 Jul;29(3):117-33. To Reference
Ref 16Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. To Reference



 

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