Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00060

Target Information
NameAlcohol dehydrogenase    
Type of targetSuccessful target    
SynonymsAldehyde reductase    
Aldo-keto reductase family 1 member A1    
DiseaseMethanol Poisoning[1]
Drug(s)FomepizoleApprovedAthylene glycol or methanol poisoning[2]
BioChemical ClassOxidoreductases acting on the CH-OH group of donors    
EC NumberEC 1.1.1.2
PathwayCaprolactam degradation
Glycerolipid metabolism
Glycolysis / Gluconeogenesis
Metabolic pathways
UniProt IDP14550
PDB Structure2ALR.    
FunctionCatalyzes the nadph-dependent reduction of a variety of aldehydes to their corresponding alcohols (by similarity).    
SequenceMAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV PMLTVDGKRVPRDAGHPLYPFNDPY
Target ValidationClick to Find Target Validation Information.    
Inhibitor2'-Monophosphoadenosine 5'-Diphosphoribose[3]
3,5-dichlorosalicylic acid[4]
Fomepizole[2]
MINALRESTAT[4]
Nicotinamide-Adenine-Dinucleotide[3]
Tolrestat[5]
Trifluoroethanol[6]
ZOPOLRESTAT[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Fomepizole: a critical assessment of current dosing recommendations. J Clin Pharmacol. 2009 Feb;49(2):130-7. Epub 2008 Nov 11. To Reference
Ref 2Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol. 2008 Jan;3(1):208-25. Epub 2007 Nov 28. To Reference
Ref 3Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 4Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. Epub 2008 Dec 24.Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. To Reference
Ref 5Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. To Reference
Ref 6Nucleic Acids Res. 2011 January; 39(Database issue): D1035¨CD1041. DrugBank 3.0: a comprehensive resource for ¡®Omics¡¯ research on drugs To Reference
Ref 7Bioorg Med Chem. 2010 Apr 1;18(7):2485-90. Epub 2010 Mar 1.Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. To Reference



 

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