Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00155

Target Information
NameSodium channel    
Type of targetSuccessful target    
DiseaseAnalgesics
[ICD9: 338   ICD10: R52]
[1]
Cardiac dysrhythmias
[ICD9: 427   ICD10: I47-I49]
[2]
Epilepsy
[ICD9: 345   ICD10: G40]
[3][4]
Pain, unspecified
[ICD9: 338,780   ICD10: R52, G89]
[1]
Drug(s)BenzocaineApprovedAnesthetic[5]
BupivacaineApprovedAnesthetic[6]
CarbamazepineApprovedEpilepsy and bipolar disorder[7]
LevobupivacaineApprovedAnesthetic[8]
MepivacaineApprovedAnesthetic[8]
OxybuprocaineApprovedAnesthetic[9]
Pachycarpine; (+)-sparteineApprovedOxytocic[10][11][12]
PermethrinApprovedInfection with Sarcoptes scabiei[13]
PhenytoinApprovedSeizures[14]
RopivacaineApprovedAnesthetic[15]
RufinamideApproved Orphan drugEpilepsy[16]
CarisbamatePhase IIIEpilepsy; Epilepsy, Focal; Seizure Disorder; Complex Partial Seizures; Epilepsy, Complex Partial[17][18][16]
Eslicarbazepine acetatePhase IIIEpilepsy[16]
RalfinamidePhase IIINeuropathic pain[19]
PhenylbutyratePhase IIUrea cycle disorders[20]
GSK1014802Phase I completedBipolar disorder[21]
2339345Phase ICough
LicarbazepineDiscontinued in Phase IIIBipolar disorder[22]
BioChemical ClassSodium channel    
Target ValidationClick to Find Target Validation Information.    
QSAR ModelClick to Find Target QSAR Model.    
InhibitorEnecadin[23]
Indol-1-yl-propyl-pyridin-4-yl-amine (Besipirdine)[23]
LOMERIZINE[23]
LUBELUZOLE[23]
PD-85639[23]
SIPATRIGINE[23]
BlockerBN82451[24]
Benzocaine[5]
Bupivacaine[6]
Carbamazepine[7]
Carisbamate[17][18][16]
E-2070[25]
Eslicarbazepine[17]
Eslicarbazepine acetate[16]
GSK1014802[21]
Levobupivacaine[8]
Licarbazepine[22]
Mepivacaine[8]
Oxybuprocaine[9]
Permethrin[13]
Phenylbutyrate[20]
Phenytoin[14]
Ralfinamide[19]
Ropivacaine[15]
Rufinamide[16]
Saxitoxin[26]
MultitargetPhenylbutyrate[20]
Ralfinamide[19]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Challenges in Analgesic Drug Development. Clin Pharmacol Ther. 2009 Aug 12. To Reference
Ref 2Pharmacology of tetrodotoxin and molecular structure of sodium channel as its target molecule. Yakushigaku Zasshi. 1994;29(3):441-5. To Reference
Ref 3Target pharmacology of topiramate, a new antiepileptic drug. Nippon Yakurigaku Zasshi. 2000 Jan;115(1):53-7. To Reference
Ref 4Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in? J Child Neurol. 1997 Nov;12 Suppl 1:S2-9. To Reference
Ref 5Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res. 2008 Jan 4;102(1):86-94. Epub 2007 Oct 25. To Reference
Ref 6Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models. Neuroscience. 2009 Jun 2;160(4):847-57. Epub 2009 Mar 19. To Reference
Ref 7Seizure exacerbation caused by antiepileptic drugs. Tidsskr Nor Laegeforen. 2008 Sep 25;128(18):2052-5. To Reference
Ref 8Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics. Anesth Analg. 2000 Dec;91(6):1499-505. To Reference
Ref 9Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett. 2009 May 1;454(3):249-53. Epub 2009 Mar 11. To Reference
Ref 103879679 To Reference
Ref 11Plant Based Drugs and Medicines, by Leslie Taylor, in Raintree Nutrition, Inc., on October 13, 2000 To Reference
Ref 1215137997 To Reference
Ref 13In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli. Med Vet Entomol. 2003 Dec;17(4):370-8. To Reference
Ref 14Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68. doi: 10.2165/00023210-200923070-00002. To Reference
Ref 15The effects of ropivacaine on sodium currents in dorsal horn neurons of neonatal rats. Anesth Analg. 2000 May;90(5):1034-8. To Reference
Ref 16Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. To Reference
Ref 17Epilepsy Res. 2009 Jan;83(1):1-43. Epub 2008 Nov 12.Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). To Reference
Ref 18Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39. To Reference
Ref 19Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. To Reference
Ref 20Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. To Reference
Ref 21GSK. Product Development Pipeline. February 2009. To Reference
Ref 22Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34. To Reference
Ref 23J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers. To Reference
Ref 24Emerging drug therapies in Huntington's disease. Expert Opin Emerg Drugs. 2009 Jun;14(2):273-97. To Reference
Ref 25Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108. To Reference
Ref 26Effect of neurotoxins on the electrical activity and contraction of the heart muscle. C R Seances Soc Biol Fil. 1997;191(3):451-71. To Reference



 

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