Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDS00157

Target Information
NameVoltage-gated sodium channel subunit alpha Nav1.8    
Type of targetSuccessful target    
TTX-R sodium channel    
Transient tetrodotoxin-resistant Na+ current    
Voltage-gated sodium channel NaV1.8    
[ICD9: 338   ICD10: R52]
Inflammatory diseases[2]
Neuropathic pain
[ICD9: 338,780   ICD10: R52, G89]
Pain, unspecified
[ICD9: 338,780   ICD10: R52, G89]
Drug(s)TetracaineApprovedSpinal anesthesia[2]
SPI-860Phase INeuropathic pain[3]
BioChemical ClassSodium channel    
UniProt IDQ9Y5Y9
Target ValidationClick to Find Target Validation Information.    
Mu O-conotoxin[1]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. J Biol Chem. 2004 Jun 11;279(24):25774-82. Epub 2004 Mar 24. To Reference
Ref 2Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23. Neuropharmacology. 2004 Mar;46(3):425-38. To Reference
Ref 3Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. To Reference
Ref 4Sensory neuron voltage-gated sodium channels as analgesic drug targets. Curr Opin Neurobiol. 2008 Aug;18(4):383-8. To Reference


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