Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00213

Target Information
NameDNA    
Type of targetSuccessful target    
DiseaseBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
[1]
Cancer, unspecific
[ICD9: 140-229   ICD10: C00-C96]
[2][3]
Human immunodeficiency virus [HIV] disease
[ICD9: 279.3   ICD10: D84.9]
[4]
Tumors
[ICD9: 140-199, 210-229   ICD10: C00-C75, C7A, C7B, D10-D36, D3A]
[5]
Drug(s)AdenineApprovedDietary shortage[6][7]
AltretamineApprovedOvarian cancer[8]
Amrubicin hclApprovedAnticancer (small-cell lung cancer)[9][10][11][12]
Amrubicin hydrochloride; Sm-5887ApprovedOncological disease (lung cancer, bladder carcinoma and gastric cancer)[13][14][15][11][16][17]
Bendamustine hydrochlorideApprovedChronic lymphocytic leukaemia
BleomycinApprovedHodgkin lymphoma[18]
BusulfanApprovedMyeloproliferative disease[19]
CarboplatinApprovedOvarian carcinoma[20]
CarmustineApprovedBrain cancer[21][22]
ChlorambucilApprovedChronic lymphatic leukemia[23]
CisplatinApprovedCancers[24]
ClofarabineApprovedAcute lymphoblastic leukemia[25]
ClofazimineApprovedCrohn's disease[26]
CyclophosphamideApprovedCancers[27]
DacarbazineApprovedMalignant melanoma[28]
DactinomycinApprovedCancers[29]
DaunorubicinApprovedAcute myeloid leukemia[29]
Dornase AlfaApprovedCystic fibrosis[30]
Elliptinium acetateApprovedOncological disease[31][32][15][33]
FurazolidoneApprovedDiarrhea[34]
Hydroxystilbamidine IsethionateApprovedBlastomycosis[35]
IdoxuridineApprovedHerpes simplex virus infection[36]
IfosfamideApprovedCancers[37]
LomustineApprovedBrain tumours[38]
MechlorethamineApprovedProstate cancer[39]
MelphalanApprovedMultiple myeloma[40]
MercaptopurineApprovedAcute lymphatic leukemia[41]
MethoxsalenApprovedPsoriasis[42]
MetronidazoleApprovedAmebiasis[43]
MitomycinApprovedGastro-intestinal and breast cancers[44]
Mitomycin AApprovedCancers[45]
Mitomycin CApprovedCancers[29]
NelarabineApprovedLeukemia[46]
NeocarzinostatinApprovedOncological disease[47][15]
NitrofurantoinApprovedUrinary tract infection[48]
OxaliplatinApprovedColorectal cancer[49]
OxamniquineApprovedSchistosomiasis[50]
PipobromanApprovedRefractory chronic myeloid leukaemia[51]
PirarubicinApprovedOncological disease (advanced bladder cancer)[52][53][15]
PrimaquineApprovedMalaria[54]
ProcarbazineApprovedHodgkin's lymphoma [55]
ProflavineApprovedAntiseptic[56]
StreptozocinApprovedMetastatic islet cell carcinoma[57]
TemozolomideApprovedGrade IV astrocytoma [58]
ThioguanineApprovedAcute myeloid leukemia[59]
Uracil mustardApprovedLymphatic malignancies[60]
Zinostatin stimalamerApprovedOncological disease[61][62][15]
BalofloxacinLaunchedGram-positive and -negative bacterial infections[63]
Ciprofloxacin XRLaunchedGram-negative bacterial infections[63]
ElsamitrucinPhase IIMantle Cell Lymphoma, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Advanced Solid Tumors[64]
EP1090Phase I/IIPrevention and treatment of HIV-1 infections
ADVAXPhase I completedHIV infection prevention
EP1300Phase IPrevention of malaria
Abetimus sodiumPhase III teminatedLupus nephritis[65]
GlufosfamideTerminated in Phase IIOvarian cancer[66]
TV-4710Terminated in Phase IISystemic lupus erythematosus[65]
Indol-3-carbinolPreclinicalFungal diseases[67]
Target ValidationClick to Find Target Validation Information.    
Inhibitor2- (3,4-Dihydroxyphenyl)Acetic Acid[68]
Abetimus sodium[65]
Balofloxacin[63]
Beta-D-Glucose[68]
Ciprofloxacin XR[63]
Glufosfamide[66]
Lipid Fragment[68]
Lomustine[38]
Phosphomethylphosphonic Acid Adenosyl Ester[68]
TV-4710[65]
Thiamin Diphosphate[68]
BreakerAltretamine[8]
Bleomycin[18]
Busulfan[19]
Carboplatin[20]
Carmustine[21][22]
Cyclophosphamide[27]
Dacarbazine[28]
Dactinomycin[29]
Dornase Alfa[30]
Duocarmycin[29]
Enediyne antibiotics[29]
Ifosfamide[37]
Mercaptopurine[41]
Metronidazole[43]
Nitracrine[3]
Nitrofurantoin[48]
Streptozocin[57]
Talisomycin[18]
Temozolomide[58]
IntercalatorActinomycin D[69]
Adriamycin[70]
Ametantrone[71]
Chlorambucil[23]
Clofazimine[26]
Daunomycin[72]
Daunorubicin[29]
Elsamitrucin[64]
Ethidium[72]
Ethidium bromide[72]
Mechlorethamine[39]
Melphalan[40]
Nogalamycin[73]
Thioguanine[59]
AdductAnthramycin[74]
Cis-[PtCl (NH3)2[75]
Cisplatin[24]
Ecteinascidins[29]
JM216[76]
Methylene blue[77]
Mitomycin A[45]
Mitomycin C[29]
Naphthyridinomycin[78]
Oxaliplatin[49]
Primaquine[54]
Procarbazine[55]
Tallimustine[79]
Minor groove binderBisbenzimide (Hoechst 33258)[80]
Di-imidazole lexitropsin[81]
Distamycin A[79]
Netropsin[82]
ModulatorUracil mustard[60]
BinderAcriflavine[83]
Adenine[6][7]
Clofarabine[25]
Furazolidone[34]
Hydroxystilbamidine Isethionate[35]
Idoxuridine[36]
Indol-3-carbinol[67]
Methoxsalen[42]
Mitomycin[44]
Nelarabine[46]
Oxamniquine[50]
Pipobroman[51]
Proflavine[56]
MultitargetClofarabine[25]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2591-4. To Reference
Ref 2DNA-intercalating ligands as anti-cancer drugs: prospects for future design. Anticancer Drug Des. 1989 Dec;4(4):241-63. To Reference
Ref 3Crosslinking of cellular DNA by nitracrine and furocoumarin derivatives. Neoplasma. 1999;46(1):50-3. To Reference
Ref 4Human immunodeficiency virus type 1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the N-terminal segments of the plant anti-HIV protein GAP31. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12208-12. To Reference
Ref 5Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 2003 Nov 1;63(21):7291-300. To Reference
Ref 6E.coli DNA Adenine Methyltransferase: Intra-Site Processivity and Substrate-Induced Dimerization and Activation. Biochemistry. 2009 Jul 6. [Epub ahead of print] To Reference
Ref 7Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages. Mol Biochem Parasitol. 2006 Jul;148(1):24-30. Epub 2006 Mar 15. To Reference
Ref 8Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26. Epub 2008 Feb 28. To Reference
Ref 919422222 To Reference
Ref 10Annual Reviews of Medicinal Chemistry 38 349 To Reference
Ref 1115620274 To Reference
Ref 12Drug Addiction: From Basic Research to Therapy By Rao S. Rapaka, Wolfgang Sadée To Reference
Ref 13ARMC 38 To Reference
Ref 14349 To Reference
Ref 15Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 1615806196 To Reference
Ref 1716796374 To Reference
Ref 18Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage. Cancer Res. 1982 Jul;42(7):2779-85. To Reference
Ref 19Different behavior of SCE-eliciting lesions induced by low and high doses of busulfan. Environ Mol Mutagen. 2007 Oct;48(8):706-14. To Reference
Ref 20The Xpc gene markedly affects cell survival in mouse bone marrow. Mutagenesis. 2009 Jul;24(4):309-16. Epub 2009 Apr 16. To Reference
Ref 21Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther. 2008 Mar;8(3):343-59. To Reference
Ref 22DNA repair and cancer stem-like cells--potential partners in glioma drug resistance? Cancer Treat Rev. 2008 Oct;34(6):558-67. Epub 2008 May 22. To Reference
Ref 23Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23. Epub 2009 Jun 9. To Reference
Ref 24Cisplatin and derived anticancer drugs: mechanism and current status of DNA binding. Met Ions Biol Syst. 1996;32:641-85. To Reference
Ref 25Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. To Reference
Ref 26Clofazimine: a review of its medical uses and mechanisms of action. J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):241-7. To Reference
Ref 27Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice. Chem Biol Interact. 2009 Aug 14;180(3):398-406. Epub 2009 Apr 2. To Reference
Ref 28Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells. Melanoma Res. 2009 Jun 25. [Epub ahead of print] To Reference
Ref 29Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215. To Reference
Ref 30Dornase alfa. BioDrugs. 1997 Dec;8(6):439-45. To Reference
Ref 31Prous Integrity database To Reference
Ref 3291123 To Reference
Ref 3316009521 To Reference
Ref 34Macrococcus brunensis sp. nov., Macrococcus hajekii sp. nov. and Macrococcus lamae sp. nov., from the skin of llamas. Int J Syst Evol Microbiol. 2003 Sep;53(Pt 5):1647-54. To Reference
Ref 35Isolation of giant silk fibroin polysomes and fibroin mRNP particles using a novel ribonuclease inhibitor, hydroxystilbamidine. J Cell Biol. 1980 Oct;87(1):292-6. To Reference
Ref 36Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7. To Reference
Ref 37Estimation of the cancer risk to humans resulting from the presence of cyclophosphamide and ifosfamide in surface water. Environ Sci Pollut Res Int. 2009 Jun 24. [Epub ahead of print] To Reference
Ref 38Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds. Acta Pol Pharm. 2007 Jan-Feb;64(1):27-33. To Reference
Ref 39Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem Res Toxicol. 2009 Jun;22(6):1151-62. To Reference
Ref 40A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards. Biochemistry. 2008 Jul 8;47(27):7147-57. Epub 2008 Jun 13. To Reference
Ref 416-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202. Epub 2009 Mar 10. To Reference
Ref 42Mutagenicity and carcinogenicity of methoxsalen plus UV-A. Arch Dermatol. 1984 May;120(5):662-9. To Reference
Ref 43Nitroreductase-mediated cell ablation in transgenic zebrafish embryos. Methods Mol Biol. 2009;546:133-43. To Reference
Ref 44Assessment of cell viability, lipid peroxidation and quantification of DNA fragmentation after the treatment of anticancerous drug mitomycin C and curcumin in cultured human blood lymphocytes. Exp Toxicol Pathol. 2009 Jul 14. [Epub ahead of print] To Reference
Ref 45Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential. J Med Chem. 2001 Aug 16;44(17):2834-42. To Reference
Ref 46Nelarabine. Drugs. 2008;68(4):439-47. To Reference
Ref 47Japan Antibiotics To Reference
Ref 48On the nature of the adaptive response induced by mitomycin C in Vibrio cholerae OGAWA 154 cells. Biochem Biophys Res Commun. 1996 Mar 27;220(3):509-14. To Reference
Ref 49Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs. Mol Cancer Ther. 2009 Jul;8(7):2015-26. Epub 2009 Jun 30. To Reference
Ref 50Binding of oxamniquine to the DNA of schistosomes. Trans R Soc Trop Med Hyg. 1989 May-Jun;83(3):373-6. To Reference
Ref 51Effects of piposulfan (Ancyte) on protein and DNA synthesis in Ehrlich ascites carcinoma. Life Sci II. 1971 Jun 8;10(11):605-12. To Reference
Ref 52ARMC 24 To Reference
Ref 53309 To Reference
Ref 54Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. Toxicology. 2007 Sep 24;239(1-2):96-107. Epub 2007 Jul 1. To Reference
Ref 55Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. DNA Repair (Amst). 2009 Jan 1;8(1):72-86. Epub 2008 Oct 21. To Reference
Ref 56Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures. DNA Cell Biol. 2009 Apr;28(4):209-19. To Reference
Ref 57Hydrodynamics-based Transfection of Pancreatic Duodenal Homeobox 1 DNA Improves Hyperglycemia and is Associated with Limited Complications in Diabetic mice. Endocr J. 2009 Jun 27. [Epub ahead of print] To Reference
Ref 58DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun. 2009 Jul 15. [Epub ahead of print] To Reference
Ref 59Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9. Epub 2009 Feb 24. To Reference
Ref 60Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases. Carcinogenesis. 1996 Apr;17(4):643-8. To Reference
Ref 61ARMC 30 To Reference
Ref 62313 To Reference
Ref 63Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. To Reference
Ref 64Spectrum. Product Development Pipeline. 2009. To Reference
Ref 65Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65. To Reference
Ref 66Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36. To Reference
Ref 67Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. Epub 2009 May 7. To Reference
Ref 68Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 69Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG. Biochemistry. 2001 May 15;40(19):5587-92. To Reference
Ref 70Interaction of adriamycin with DNA as studied by resonance Raman spectroscopy. Nucleic Acids Res. 1982 Jun 25;10(12):3803-16. To Reference
Ref 71Interactions of antitumor agents Ametantrone and Mitoxantrone (Novatrone) with double-stranded DNA. Biochem Pharmacol. 1985 Dec 15;34(24):4203-13. To Reference
Ref 7231P NMR spectra of ethidium, quinacrine, and daunomycin complexes with poly(adenylic acid).poly(uridylic acid) RNA duplex and calf thymus DNA. Biochemistry. 1989 Apr 4;28(7):2804-12. To Reference
Ref 73Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution. J Mol Biol. 1999 Jul 16;290(3):699-716. To Reference
Ref 74Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity. Biochemistry. 1994 Nov 22;33(46):13593-610. To Reference
Ref 75DNA interactions of a novel platinum drug, cis-[PtCl(NH3)2(N7-acyclovir)]+. Mol Pharmacol. 1998 May;53(5):846-55. To Reference
Ref 76Oral platinum analogue JM216, a radiosensitizer in oxic murine cells. Int J Radiat Biol. 1997 Dec;72(6):675-83. To Reference
Ref 77Photoluminescence of CdTe nanocrystals modulated by methylene blue and DNA. A label-free luminescent signaling nanohybrid platform. Phys Chem Chem Phys. 2009 Jul 7;11(25):5062-9. Epub 2009 Mar 26. To Reference
Ref 78Naphthyridinomycin-DNA adducts: a molecular modeling study. J Antibiot (Tokyo). 1991 Aug;44(8):885-94. To Reference
Ref 79Development of distamycin-related DNA binding anticancer drugs. Expert Opin Investig Drugs. 2001 Sep;10(9):1703-14. To Reference
Ref 80Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex. Nucleic Acids Res. 1994 May 11;22(9):1607-12. To Reference
Ref 81Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. Structure. 1997 Aug 15;5(8):1033-46. To Reference
Ref 82Drug-DNA binding specificity: binding of netropsin and distamycin to poly(d2NH2A-dT). Biopolymers. 1990;30(1-2):223-7. To Reference
Ref 83Acriflavine binding and DNA stability. Biofizika. 1986 Nov-Dec;31(6):940-3. To Reference



 

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