Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDS00213

Target Information
Type of targetSuccessful target    
DiseaseBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Cancer, unspecific
[ICD9: 140-229   ICD10: C00-C96]
Human immunodeficiency virus [HIV] disease
[ICD9: 279.3   ICD10: D84.9]
[ICD9: 140-199, 210-229   ICD10: C00-C75, C7A, C7B, D10-D36, D3A]
Drug(s)AdenineApprovedDietary shortage[6][7]
AltretamineApprovedOvarian cancer[8]
Amrubicin hclApprovedAnticancer (small-cell lung cancer)[9][10][11][12]
Amrubicin hydrochloride; Sm-5887ApprovedOncological disease (lung cancer, bladder carcinoma and gastric cancer)[13][14][15][11][16][17]
Bendamustine hydrochlorideApprovedChronic lymphocytic leukaemia
BleomycinApprovedHodgkin lymphoma[18]
BusulfanApprovedMyeloproliferative disease[19]
CarboplatinApprovedOvarian carcinoma[20]
CarmustineApprovedBrain cancer[21][22]
ChlorambucilApprovedChronic lymphatic leukemia[23]
ClofarabineApprovedAcute lymphoblastic leukemia[25]
ClofazimineApprovedCrohn's disease[26]
DacarbazineApprovedMalignant melanoma[28]
DaunorubicinApprovedAcute myeloid leukemia[29]
Dornase AlfaApprovedCystic fibrosis[30]
Elliptinium acetateApprovedOncological disease[31][32][15][33]
Hydroxystilbamidine IsethionateApprovedBlastomycosis[35]
IdoxuridineApprovedHerpes simplex virus infection[36]
LomustineApprovedBrain tumours[38]
MechlorethamineApprovedProstate cancer[39]
MelphalanApprovedMultiple myeloma[40]
MercaptopurineApprovedAcute lymphatic leukemia[41]
MitomycinApprovedGastro-intestinal and breast cancers[44]
Mitomycin AApprovedCancers[45]
Mitomycin CApprovedCancers[29]
NeocarzinostatinApprovedOncological disease[47][15]
NitrofurantoinApprovedUrinary tract infection[48]
OxaliplatinApprovedColorectal cancer[49]
PipobromanApprovedRefractory chronic myeloid leukaemia[51]
PirarubicinApprovedOncological disease (advanced bladder cancer)[52][53][15]
ProcarbazineApprovedHodgkin's lymphoma [55]
StreptozocinApprovedMetastatic islet cell carcinoma[57]
TemozolomideApprovedGrade IV astrocytoma [58]
ThioguanineApprovedAcute myeloid leukemia[59]
Uracil mustardApprovedLymphatic malignancies[60]
Zinostatin stimalamerApprovedOncological disease[61][62][15]
BalofloxacinLaunchedGram-positive and -negative bacterial infections[63]
Ciprofloxacin XRLaunchedGram-negative bacterial infections[63]
ElsamitrucinPhase IIMantle Cell Lymphoma, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Advanced Solid Tumors[64]
EP1090Phase I/IIPrevention and treatment of HIV-1 infections
ADVAXPhase I completedHIV infection prevention
EP1300Phase IPrevention of malaria
Abetimus sodiumPhase III teminatedLupus nephritis[65]
GlufosfamideTerminated in Phase IIOvarian cancer[66]
TV-4710Terminated in Phase IISystemic lupus erythematosus[65]
Indol-3-carbinolPreclinicalFungal diseases[67]
Target ValidationClick to Find Target Validation Information.    
Inhibitor2- (3,4-Dihydroxyphenyl)Acetic Acid[68]
Abetimus sodium[65]
Ciprofloxacin XR[63]
Lipid Fragment[68]
Phosphomethylphosphonic Acid Adenosyl Ester[68]
Thiamin Diphosphate[68]
Dornase Alfa[30]
Enediyne antibiotics[29]
IntercalatorActinomycin D[69]
Ethidium bromide[72]
Cis-[PtCl (NH3)2[75]
Methylene blue[77]
Mitomycin A[45]
Mitomycin C[29]
Minor groove binderBisbenzimide (Hoechst 33258)[80]
Di-imidazole lexitropsin[81]
Distamycin A[79]
ModulatorUracil mustard[60]
Hydroxystilbamidine Isethionate[35]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
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